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Keywords: Cardiogenesis
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Journal Articles
Journal: Development
Development (2018) 145 (24): dev171983.
Published: 20 December 2018
... transcription factors Cardiogenesis Epigenetic regulator Heart regeneration Heart disease, the leading cause of death worldwide, arises primarily from loss of or damage to cardiomyocytes – the muscle cells that generate the contractile force of the heart. Cardiomyocyte loss can occur in response...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev152488.
Published: 29 March 2018
...Hinako Kidokoro; Sayuri Yonei-Tamura; Koji Tamura; Gary C. Schoenwolf; Yukio Saijoh ABSTRACT In the initiation of cardiogenesis, the heart primordia transform from bilateral flat sheets of mesoderm into an elongated midline tube. Here, we discover that this rapid architectural change is driven...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 306–317.
Published: 15 January 2016
...Shaad M. Ahmad; Pritha Bhattacharyya; Neal Jeffries; Stephen S. Gisselbrecht; Alan M. Michelson Cardiogenesis involves the coordinated regulation of multiple biological processes by a finite set of transcription factors (TFs). Here, we show that the Forkhead TFs Checkpoint suppressor homologue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 846–857.
Published: 1 March 2015
... analysis on single cardiac lineage cells provides a high-resolution view of cardiac fate choice in the mouse embryo and during stem cell differentiation. Cardiac progenitor cells Cardiogenesis Embryonic stem cell Nkx2-5 Differentiation The heart is the first organ to form during mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5357–5368.
Published: 15 December 2011
... Competing interests statements The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4627–4638.
Published: 1 November 2011
...Aaron N. Johnson; Mayssa H. Mokalled; Tom N. Haden; Eric N. Olson Intercellular signal transduction pathways regulate the NK-2 family of transcription factors in a conserved gene regulatory network that directs cardiogenesis in both flies and mammals. The Drosophila NK-2 protein Tinman (Tin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1297–1308.
Published: 1 April 2011
... . Watt A. J. , Battle M. A. , Li J. , Duncan S. A. ( 2004 ). GATA4 is essential for formation of the proepicardium and regulates cardiogenesis . Proc. Natl. Acad. Sci. USA 101 , 12573 - 12578 . Wheldon L. M. , Haines B. P. , Rajappa R. , Mason I...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 2989–3000.
Published: 15 September 2010
... disorders. Congenital heart disease, the most common of all birth defects in humans, arises from abnormalities in the early stages of cardiogenesis. The vertebrate heart is formed from two mesoderm populations or ‘heart fields’, termed the first and second heart fields, which arise from common origins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1919–1929.
Published: 1 June 2010
... of California, San Diego, La Jolla, CA 92093, USA ‡ Present address: Department of Cardiology, Children's Hospital Boston, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA Competing interests statement 6 4 2010 © 2010. Tbx20 Cardiogenesis Cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1465–1474.
Published: 1 May 2009
... Myelopoiesis Cardiogenesis GATA factors Second heart field Haemangioblasts Transcriptional regulation Evolution Adult stem cells Zebrafish Of the several candidates for stem cells in the adult heart, only one, in addition to having the classical stem cell characteristics of multipotentiality...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 317–326.
Published: 15 January 2009
... inductive signals Dpp and Wg. Genetic interactions show that tup cooperates with tin, pnr and Doc in heart cell specification. Germ layer-specific loss-of-function and rescue experiments reveal that Tup also functions in the ectoderm to regulate cardiogenesis and implicate the involvement of different LIM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4585–4593.
Published: 15 November 2006
...Kai Jiao; Melissa Langworthy; Lorene Batts; Chris B. Brown; Harold L. Moses; H. Scott Baldwin The transforming growth factorβ (Tgfβ) signaling pathway plays crucial roles in many biological processes. To understand the role(s) of Tgfβ signaling during cardiogenesis in vivo and to overcome the early...
Journal Articles
Journal: Development
Development (2006) 133 (13): 2575–2584.
Published: 1 July 2006
... acetate followed by Reynolds' lead citrate. Sections were imaged with a LEO EM-910 transmission electron microscope. © 2006. 2006 Tbx5 Holt-Oram Syndrome Cardiogenesis Cardiac Heart Xenopus Cell cycle S-phase Proliferation T-box Hyperplastic growth of the vertebrate...
Journal Articles
Journal: Development
Development (2006) 133 (12): 2435–2445.
Published: 15 June 2006
... found that Fgf8 is necessary for Pea3 expression within the AHF itself, and may also modulate Bmp4 expression levels. * Author for correspondence (e-mail: e.meyers@cellbio.duke.edu ) 18 4 2006 © 2006. 2006 Fgf8 Anterior heart field Cardiogenesis Cell Survival...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1175–1182.
Published: 15 March 2006
... the lethality of Hand mutants, and cardiac expression of a human HAND gene, or the caspase inhibitor P35,partially rescued the cardiac and lymph gland phenotypes. These findings demonstrate evolutionarily conserved functions of HAND transcription factors in Drosophila and mammalian cardiogenesis, and reveal...
Journal Articles
Journal: Development
Development (2005) 132 (11): 2669–2678.
Published: 1 June 2005
...: eric.olson@utsouthwestern.edu ) 4 4 2005 ©2005. 2005 Cardiac gene expression Skeletal muscle gene expression MEF2 binding site E-box Cardiogenesis Mouse Anterior heart field Heart development is a precisely orchestrated process in which even subtle perturbations can have...
Journal Articles
Journal: Development
Development (2005) 132 (3): 553–563.
Published: 1 February 2005
... interaction between members of the T-box gene family. * Author for correspondence (e-mail: frank_conlon@med.unc.edu ) 23 11 2004 ©2005. 2005 Tbx5 Tbx20 T-Box T-domain Cardiogenesis Cardiac Heart Development Xenopus laevis 293T cells were plated at 1×10 6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4709–4723.
Published: 1 October 2004
... 2004. 2004 Nkx2.5 BMP YY1 GATA SMADs Cardiogenesis Chick The heart is the first organ to develop during vertebrate embryogenesis and arises from cardiac progenitor cells that migrate into the anterior lateral mesoderm during gastrulation ( DeHaan,1965 ; Rawles,1943 ; Rosenquist...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (3): 669–679.
Published: 1 February 2004
..., the gene is expressed throughout the entire myocardium, even after differentiation of distinct atrial and ventricular chambers. By contrast, the mammalian MLC2 a and MLC2 v genes are progressively restricted in their domains of expression during cardiogenesis, yielding reciprocal patterns of expression...
Journal Articles
Journal: Development
Development (2003) 130 (13): 3027–3038.
Published: 1 July 2003
...-mesodermal overexpression of pannier ectopically expands tinman expression, whereas overexpression of u-shaped inhibits cardiogenesis. Both factors are also required for maintaining dpp expression after germ band retraction in the dorsal ectoderm. Thus, we propose that Pannier mediates as well as maintains...