... and complex morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis. Cardiac morphogenesis Extracellular matrix Heart development Heart regeneration Heart development is a highly complex...

... types. Their functions in cardiac progenitor differentiation and cardiac morphogenesis are unknown. To avoid early embryonic lethality and study NFP function in later cardiac development, Numb and Numbl were deleted specifically in heart to generate myocardial double-knockout (MDKO) mice. MDKOs were...

...@email.arizona.edu ; lionelchristiaen@berkeley.edu ) * Present address: Department of Molecular and Cellular Biology, Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724,USA 5 7 2007 © 2007. 2007 FGF signaling Ascidian Cardiac morphogenesis Directed cell...

... Cardiac morphogenesis Epithelial-mesenchymal transition EMT Atrioventricular valves Cardiac malformations attributable to aberrant development of the atrioventricular (AV) valvuloseptal complex are among the most common forms of congenital heart disease ( Pierpont et al.,2000 ). Development...

... Epithelial-mesenchymal transition Cardiac morphogenesis Mouse Abnormal valve development is a common human congenital anomaly, affecting approximately 1% of all live births( Armstrong and Bischoff, 2004 ; Barnett and Desgrosellier,2003 ). Because of its prevalence, it is important to understand...

... © 2004. 2004 Homeobox Transcription factor Cardiac morphogenesis Repressor Vasculogenesis Endocardial cushion Epithelial-mesenchymal transformation Vegf Hhex , as well as its highly conserved human and chick homologues, HHEX and Prh , was first cloned in 1992( Bedford et al...

... in cardiovascular development: the connection between function and form during cardiac morphogenesis, and the requirement for cardiac function during vascular development. Diminished atrial function in MLC2a-null embryos resulted in a number of consistent secondary abnormalities in both cardiac morphogenesis...

.... Homozygotes of the middle copy-number lines, in which Rho GDIα expression was increased four-fold over normal levels, were also embryonic lethal. Cardiac morphogenesis in these embryos was disrupted, with incomplete looping, lack of chamber demarcation, hypocellularity and lack of trabeculation. Cell...

... for correspondence (e-mail: radice@mail.med.upenn.edu ) 05 12 2000 23 01 2001 © 2001 The Company of Biologists Ltd. 2001 Cell adhesion Cardiac morphogenesis Outflow tract Apoptosis Mouse N-cadherin The correct spatial organization of cells is critical for normal tissue...

... identified two downstream modulators of the BMP/ALK2 signaling pathway that also can regulate cardiac orientation. Collectively, these results define a BMP/ALK2-mediated pathway on the right side of the Xenopus embryo and, moreover, suggest that left-right patterning preceding cardiac morphogenesis involves...

... vertebrate cardiogenesis, a series of maturational steps within the ventricular muscle lineage must occur for appropriate chamber development. Ventricular chamber Myosin light chain Cardiac morphogenesis RXRα Heart Mouse © 1998 by Company of Biologists 1998 20 10 1998 20 08...