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Keywords: Cardiac development
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Journal: Development
Development (2019) 146 (12): dev180398.
Published: 14 June 2019
.../ Summary: Using single cell transcriptomics to inspect Pitx2 function in cardiac development and left-right cellular specification, this study characterizes all deviations in cell composition, cellular state and differentiation trajectories. Pitx2 Left-right asymmetry Single cell RNA-seq Cardiac...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2018) 145 (1): dev159905.
Published: 8 January 2018
... commitment within the CPC population during both hPSC differentiation and mouse embryogenesis. Wnt5a, which has been shown to exert an inhibitory influence on Wnt signaling during cardiac development, was dynamically expressed during vascular commitment of hPSC-derived CPCs, and ectopic Wnt5a promoted...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2016) 143 (3): 373–386.
Published: 1 February 2016
...Timm Haack; Salim Abdelilah-Seyfried Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel...
Journal Articles
Journal: Development
Development (2016) 143 (2): 197–210.
Published: 15 January 2016
....1749-6632.1965.tb49389.x de la Pompa , J. L. and Epstein , J. A. ( 2012 ). Coordinating tissue interactions: Notch signaling in cardiac development and disease . Dev. Cell   22 , 244 - 254 . 10.1016/j.devcel.2012.01.014 de Laat , W. and Duboule , D. ( 2013...
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (23): 4418–4431.
Published: 1 December 2014
... to regenerate the damaged tissue, making it one of the leading causes of morbidity and mortality worldwide. In this Primer we discuss how insights into the molecular and cellular framework underlying cardiac development can be used to guide the in vitro specification of cardiomyocytes, whether by directed...
Journal Articles
Journal: Development
Development (2014) 141 (17): 3292–3297.
Published: 1 September 2014
... in cardiac development by Sema6D reverse signalling . Nat. Cell Biol. 6 , 1204 - 1211 . 10.1038/ncb1193 Toyofuku T. , Yoshida J. , Sugimoto T. , Zhang H. , Kumanogoh A. , Hori M. , Kikutani H. ( 2005 ). FARP2 triggers signals for Sema3A-mediated axonal...
Journal Articles
Journal: Development
Development (2014) 141 (15): 2959–2971.
Published: 1 August 2014
...Linda Cambier; Markus Plate; Henry M. Sucov; Mohammad Pashmforoush A complex regulatory network of morphogens and transcription factors is essential for normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac mesoderm that is central to the regulatory pathways mediating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4165–4176.
Published: 15 October 2013
...Jan Willem Buikema; Ahmed S. Mady; Nikhil V. Mittal; Ayhan Atmanli; Leslie Caron; Pieter A. Doevendans; Joost P. G. Sluijter; Ibrahim J. Domian In mammals, cardiac development proceeds from the formation of the linear heart tube, through complex looping and septation, all the while increasing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 1931–1940.
Published: 1 June 2012
... regulators of the response of second heart field progenitors to Wnt/β-catenin signaling and that they act by restraining Wnt/β-catenin signaling during cardiac development. References Abdul-Ghani M. , Dufort D. , Stiles R. , De Repentigny Y. , Kothary R. , Megeney L...
Includes: Supplementary data
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Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (18): 3607–3618.
Published: 15 September 2006
... functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3 - Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Heart development Endocardial cushion Gata4 Heart valves Cardiac development...
Includes: Supplementary data
Journal Articles