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Keywords: Cancer
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Journal Articles
Journal: Development
Development (2024) 151 (5): dev202392.
Published: 28 February 2024
... and highlighting differences between developmentally programmed and induced polyploidy. Cancer Cell size Gene expression Polyploidy Nederlandse Organisatie voor Wetenschappelijk Onderzoek http://dx.doi.org/10.13039/501100003246 OCENW.KLEIN.258 Cancer Genomics Center http...
Journal Articles
Journal: Development
Development (2023) 150 (3): dev201352.
Published: 10 February 2023
... the recycling of its cargo receptor Evi/Wntless. We also describe the regulation of Wnt export through a post-translational mechanism and review the importance of Wnt secretion for organ development and cancer, and as a future biomarker. More frequently, aberrant Wnt secretion is associated with cancer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199814.
Published: 3 September 2021
... regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine. * Author for correspondence ( hoodless...
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181636.
Published: 2 January 2020
... regeneration, including genetic, cellular and metabolic heterogeneity, changes in circulating factors, and the complex roles of immune cells and immune modulation at systemic and local levels. We suggest that certain mechanisms enabling regeneration may be co-opted by cancer to promote growth at primary...
Journal Articles
Journal: Development
Development (2018) 145 (18): dev151407.
Published: 17 September 2018
... the molecular factors involved in cilium formation and removal, the relevance of these processes to development and how recent findings are highlighting new possibilities for therapeutic intervention in disease. Primary cilia Ciliopathies Cilium assembly Cilium disassembly Cancer Cilia...
Journal Articles
Journal: Development
Development (2018) 145 (13): dev153817.
Published: 6 July 2018
... - 98 . 10.1016/j.ydbio.2016.01.041 Bracken , C. P. , Khew-Goodall , Y. and Goodall , G. J. ( 2015 ). Network-Based Approaches to Understand the Roles of miR-200 and Other microRNAs in Cancer . Cancer Res.   75 , 2594 - 2599 . 10.1158/0008-5472.CAN-15-0287 Brennecke...
Includes: Supplementary data
Journal Articles
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Advocacy
Journal: Development
Development (2018) 145 (12): dev165902.
Published: 26 June 2018
.... , Kilgore , J. , Williams , N. S. , et al. ( 2009 ). Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer . Nat. Chem. Biol.   5 , 100 - 107 . 10.1038/nchembio.137 Conklin , E. G. ( 1905 ). The Organization and Cell-lineage...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
... (University of Pennsylvania, Philadelphia, USA) reported that inflammatory cytokines are upregulated in mouse models of FOP, and that HO is attenuated in mice lacking macrophages and/or mast cells. TGFβ suppresses most cancers at early stages of tumorigenesis, but later promotes tumorigenesis...
Journal Articles
Journal: Development
Development (2017) 144 (6): 968–975.
Published: 15 March 2017
... cancer therapy and regenerative medicine. References Alexandrov , L. B. , Nik-Zainal , S. , Wedge , D. C. , Aparicio , S. A. J. R. , Behjati , S. , Biankin , A. V. , Bignell , G. R. , Bolli , N. , Borg , A. , Børresen-Dale , A.-L. , et al. ( 2013a...
Journal Articles
Journal: Development
Development (2016) 143 (16): 2907–2919.
Published: 15 August 2016
... for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture . PLoS ONE   7 , e34063 . 10.1371/journal.pone.0034063 Chen , F. ( 2012 ). JNK-induced apoptosis, compensatory growth, and cancer stem cells . Cancer Res.   72 , 379 - 386 . 10.1158/0008-5472.CAN-11-1982 Classen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2247–2251.
Published: 1 June 2013
... no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Neural crest cells Epithelium-to-mesenchyme transition Cell migration Chemotaxis Contact-inhibition of locomotion Cancer Neurocristopathies The neural crest (NC) is a multipotent stem cell...
Journal Articles
Journal: Development
Development (2013) 140 (8): 1807–1818.
Published: 15 April 2013
...Madeline Hayes; Mizue Naito; Avais Daulat; Stephane Angers; Brian Ciruna Using zebrafish, we have characterised the function of Protein tyrosine kinase 7 (Ptk7), a transmembrane pseudokinase implicated in Wnt signal transduction during embryonic development and in cancer. Ptk7 is a known regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: Primer Series
Development (2013) 140 (1): 3–12.
Published: 1 January 2013
... the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer. Propagating a stable genome is part of normal cell...
Journal Articles
Journal: Development
Development (2012) 139 (11): 1895–1902.
Published: 1 June 2012
... shown that Tet family proteins and 5hmC are involved in normal development as well as in many diseases. In this Primer we provide an overview of the role of Tet family proteins and 5hmC in development and cancer. * Author for correspondence ( yujiang_shi@hms.harvard.edu ) Competing interests...
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (7): 1355–1364.
Published: 1 April 2008
..., Aichi 474-8522, Japan 24 1 2008 © 2008. 2008 Src E-cadherin Armadillo Drosophila Trachea Cancer The concerted dissociation and re-establishment of cell-cell adhesion in epithelial cells is essential for morphogenesis, but studies of the cellular bases of those...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (2): 363–369.
Published: 15 January 2006
...Konstantinos Meletis; Valtteri Wirta; Sanna-Maria Hede; Monica Nistér; Joakim Lundeberg; Jonas Frisén There is increasing evidence that tumors are heterogeneous and that a subset of cells act as cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of stem cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3767–3776.
Published: 15 August 2005
... with an increased risk of subsequent neoplasia. In both mouse and human pancreas, acinar-to-ductal metaplasia has been implicated in the generation of cancer precursors. We show that pancreatic epithelial explants undergo spontaneous acinar-to-ductal metaplasia in response to EGFR signaling, and that this change...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2365–2375.
Published: 15 May 2005
... a central role in tumourigenesis; mutations in PTEN , a negative regulator of the pathway, occur at remarkably high frequency in several different human cancers (reviewed by Goberdhan and Wilson,2003b ). Insulin signalling Drosophila Cancer TOR Diabetes Nutrition SLC36 References...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (17): 4103–4109.
Published: 1 September 2002
... 2002. 2002 Growth PtdIns P 3 Pten Cancer Tumor suppressor Insulin PI 3 kinase In Drosophila , the homologs of the mammalian insulin receptor (IR)/insulin-like growth factor receptor (IGFR), InR, and insulin receptor substrates (IRS1-4), Chico, control size (via regulation...