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Keywords: CXCR4
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Journal Articles
Journal: Development
Development (2017) 144 (11): 2045–2058.
Published: 1 June 2017
... activity, precocious differentiation and increased apoptosis, resulting in a severe DG growth defect in adult mice. COUP-TFI-deficient cells express high levels of the chemokine receptor Cxcr4 and migrate abnormally, forming heterotopic clusters of differentiated granule cells along their paths. Conversely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2334–2343.
Published: 1 July 2016
... receptor CXCR4. Interestingly, the absence of CXCR4 signaling in spinal MNs is known to result in improper extension of the axons into the dorsal side of the spinal cord. Here, we report that the MN-specific ISL1-LHX3 complex directly transactivates the Stam1 gene and that STAM1 functions in determining...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 582–588.
Published: 15 February 2016
... are poorly identified. The recent demonstrations that the SDF1/CXCR4 axis is implicated in NC chemotactic guidance and impaired in cortical interneurons of mouse DGS models prompted us to search for genetic interactions between Tbx1 , Sdf1 ( Cxcl12 ) and Cxcr4 in pharyngeal NCs and to investigate the effect...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4199–4205.
Published: 15 November 2014
... through the chemokine receptor CXCR4 to guide cell migration during embryogenesis, immune cell trafficking and cancer metastasis. Here and in the accompanying poster, we provide an overview of chemokine signaling, focusing on CXCL12, and we highlight some of the different chemokine-dependent strategies...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1857–1863.
Published: 1 May 2014
...Philipp Abe; Wiebke Mueller; Dagmar Schütz; Fabienne MacKay; Marcus Thelen; Penglie Zhang; Ralf Stumm The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2909–2914.
Published: 15 July 2011
... that PGCs respond preferentially to one of the paralogs and define the molecular basis for this biased behavior. We find that a single amino acid exchange switches the relative affinity of the Cxcl12 ligands for one of the duplicated Cxcr4 receptors, thereby determining the functional specialization of each...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (18): 4279–4286.
Published: 15 September 2003
... in other organisms, suggest that at least part of this process is in response to secreted signals from other tissues. Recent genetic evidence in zebrafish has shown that the interaction between stromal cell-derived factor 1 (SDF1) and its G-protein-coupled receptor CXCR4, already known to control many...
Includes: Multimedia, Supplementary data