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Keywords: CSL
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Journal Articles
Journal: Development
Development (2023) 150 (11): dev201785.
Published: 8 June 2023
... at target genes, forming a complex with the DNA-binding transcription factor CSL [CBF1/Su(H)/LAG-1] and co-activator Mastermind. However, CSL lacks its own nuclear localisation sequence, and it remains unclear where the tripartite complex is formed. To probe the mechanisms involved, we designed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
...Katherine Leisan Luo; Ryan S. Underwood; Iva Greenwald ABSTRACT During animal development, ligand binding releases the intracellular domain of LIN-12/Notch by proteolytic cleavage to translocate to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1892–1902.
Published: 1 May 2013
...Qi Dai; Celia Andreu-Agullo; Ryan Insolera; Li Chin Wong; Song-Hai Shi; Eric C. Lai The activity of the Notch pathway revolves around a CSL-class transcription factor, which recruits distinct complexes that activate or repress target gene expression. The co-activator complex is deeply conserved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (22): 3999–4009.
Published: 15 November 2007
...-12 Notch LAG-1 CSL FOS-1 Fos Jun Specification Transcription The Notch pathway specifies numerous cell fates during development. How can diverse tissues be generated under the control of a single reiteratively utilized pathway? Understanding mechanisms that directly influence target...