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Keywords: CBFβ
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Journal Articles

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium

In collection:
Cardiovascular development and regeneration , Stem cells & regeneration
Michael Lie-A-Ling, Elli Marinopoulou, Andrew J. Lilly, Mairi Challinor, Rahima Patel, Christophe Lancrin, Valerie Kouskoff, Georges Lacaud
Journal: Development
Development (2018) 145 (5): dev149419.
https://doi.org/10.1242/dev.149419
Published: 12 March 2018
... embryonic stem cell differentiation system to determine if and how RUNX1 dosage affects hemogenic endothelium differentiation. The use of inducible Runx1 expression combined with alterations in the expression of the RUNX1 co-factor CBFβ allowed us to evaluate a wide range of RUNX1 levels. We demonstrate...
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Includes: Supplementary data
Journal Articles

The C. elegans CBFβ homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal

Hiroshi Kagoshima, Rachael Nimmo, Nicole Saad, Junko Tanaka, Yoshihiro Miwa, Shohei Mitani, Yuji Kohara, Alison Woollard
Journal: Development
Development (2007) 134 (21): 3905–3915.
https://doi.org/10.1242/dev.008276
Published: 1 November 2007
...Hiroshi Kagoshima; Rachael Nimmo; Nicole Saad; Junko Tanaka; Yoshihiro Miwa; Shohei Mitani; Yuji Kohara; Alison Woollard In this report, we investigate the C. elegans CBFβ homologue,BRO-1. bro-1 mutants have a similar male-specific sensory ray loss phenotype to rnt-1 (the C. elegans homologue...
View article titled, The C. elegans <span class="search-highlight">CBFβ</span> homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal
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Includes: Supplementary data
Journal Articles

The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor

Jill Wildonger, Richard S. Mann
Journal: Development
Development (2005) 132 (10): 2263–2272.
https://doi.org/10.1242/dev.01824
Published: 15 May 2005
... transcriptional repressor. * Author for correspondence (e-mail: rsm10@columbia.edu ) 10 3 2005 ©2005. 2005 AML1 (RUNX1) AML1-ETO MTG8 Lozenge CBFβ Drosophila eye RUNX1T1 The human disease acute myelogenous leukemia (AML) is characterized by the proliferation...
View article titled, The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
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Journal Articles

Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development

Joshua S. Kaminker, Rajan Singh, Tim Lebestky, Huajun Yan, Utpal Banerjee
Journal: Development
Development (2001) 128 (14): 2639–2648.
https://doi.org/10.1242/dev.128.14.2639
Published: 15 July 2001
... of proteins and the β-subunit is encoded by the CBFβ gene. In Drosophila, two genes encoding α-subunits, runt and lozenge , and two genes encoding β-subunits, Big brother and Brother, have been previously identified. Here, a sensitized genetic screen was used to isolate mutant alleles of the Big brother gene...
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