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Keywords: Branching morphogenesis
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Journal Articles
Journal: Development
Development (2022) 149 (1): dev197657.
Published: 6 January 2022
... ). In all cases, glands must contain ‘end-pieces’ (required for the synthesis of glandular secretions) and ‘ducts’ (required for fluid transport and regulation of tonicity). Box 1. Coiling and branching morphogenesis In contrast to a simple single tip outgrowth mode during coiling, as occurs in sweat...
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199544.
Published: 2 December 2021
..., it identifies a mechanism involving RTK signaling and cell proliferative activity at the branch tip for branching morphogenesis that is apparently conserved across the animal kingdom. 19 2 2021 26 10 2021 © 2021. Published by The Company of Biologists Ltd 2021 * Present address...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev199460.
Published: 20 May 2021
... Ltd 2021 Summary: Micro-CT imaging demonstrates that physical space constraints of the chest cavity early in gestation could contribute to altered lung development in a genetic model of congenital diaphragmatic hernia. CDH WT1 Branching morphogenesis Diaphragm development Micro-CT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev199386.
Published: 29 April 2021
...Adam Packard; William H. Klein; Frank Costantini ABSTRACT Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret -expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev190785.
Published: 23 March 2021
..., the exact role of actomyosin contractility in force transmission and the related transcriptional changes during morphogenesis are not fully understood. Here, we report a mechanogenetic role of the actomyosin complex in branching morphogenesis using an organotypic culture system of mouse embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
... of mammary epithelium. Our results demonstrate a pleiotropic role for FGF signaling in mammary fibroblasts, with implications for regulation of mammary stromal functions and epithelial branching morphogenesis. * Author for correspondence ( koledova@med.muni.cz ) Competing interests The authors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev175810.
Published: 1 May 2019
... shuttling is largely dispensable in epithelial progenitors for both branching morphogenesis and sacculation. However, if maintained transcriptionally active in airways, nuclear Yap profoundly alters proximal-distal identity and halts epithelial differentiation. Taken together, these observations provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
... examined the branching of the UB epithelia at E13.5 and E16 in 3D by OPT using Troma-1 staining the UB trunks and Ezrin enriched at the tips ( Fig. 3 A-D″). Following OPT, reconstructed mutant kidneys showed a significant decrease in branching morphogenesis at E13.5 ( Fig. 3 A-B″). At E16, CDs developed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4377–4385.
Published: 1 December 2017
...James G. Lefevre; Kieran M. Short; Timothy O. Lamberton; Odyssé Michos; Daniel Graf; Ian M. Smyth; Nicholas A. Hamilton Metanephric kidney development is orchestrated by the iterative branching morphogenesis of the ureteric bud. We describe an underlying patterning associated with the ramification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3777–3788.
Published: 15 October 2017
... demonstrate that PTPRB negatively regulates branching morphogenesis in the mouse mammary epithelium. We show that Ptprb is highly expressed in adult mammary stem cells and also, although at lower levels, in oestrogen receptor-positive luminal cells. During mammary development, Ptprb expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3177–3188.
Published: 1 September 2017
...Elisabeth A. Rutledge; Jean-Denis Benazet; Andrew P. McMahon Branching morphogenesis creates arborized epithelial networks. In the mammalian kidney, an epithelial progenitor pool at ureteric branch tips (UBTs) creates the urine-transporting collecting system. Using region-specific mouse reporter...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2961–2968.
Published: 15 August 2017
.... References Affolter , M. and Caussinus , E. ( 2008 ). Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture . Development   135 , 2055 - 2064 . 10.1242/dev.014498 Affolter , M. , Zeller , R. and Caussinus , E. ( 2009...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (13): 2469–2479.
Published: 1 July 2017
... gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7 −/− placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2294–2305.
Published: 15 June 2017
...Lemonia Chatzeli; Marcia Gaete; Abigail S. Tucker Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2200–2211.
Published: 15 June 2017
...William P. Daley; Kazue Matsumoto; Andrew D. Doyle; Shaohe Wang; Brian J. DuChez; Kenn Holmbeck; Kenneth M. Yamada Branching morphogenesis of developing organs requires coordinated but poorly understood changes in epithelial cell-cell adhesion and cell motility. We report that Btbd7 is a crucial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 657–663.
Published: 15 February 2017
...-autonomous expansion of tracheal tubes in Drosophila . Curr. Biol.   20 , 62 - 68 . 10.1016/j.cub.2009.11.062 Ghabrial , A. S. and Krasnow , M. A. ( 2006 ). Social interactions among epithelial cells during tracheal branching morphogenesis . Nature   441 , 746 - 749 . 10.1038...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 983–993.
Published: 15 March 2016
...Robert J. Huebner; Neil M. Neumann; Andrew J. Ewald Mammary branching morphogenesis is regulated by receptor tyrosine kinases (RTKs). We sought to determine how these RTK signals alter proliferation and migration to accomplish tube elongation in mouse. Both behaviors occur but it has been difficult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3239–3251.
Published: 15 September 2015
... Branching morphogenesis Organoid Regenerative potential CD10 Terminal ductal-lobular units Collagen gel The mammary gland (MG) develops from the anlage, a cluster of specified ectodermal cells forming a rudimentary ductal tree before birth ( Sternlicht, 2006 ). Puberty induces outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1180–1192.
Published: 15 March 2015
... factor receptors 1 and 2 in the ureteric bud . Dev. Biol.   276 , 403 - 415 . 10.1016/j.ydbio.2004.09.002 The canonical Wnt signaling pathway controls both UB branching morphogenesis and nephrogenesis. Specifically, Wnt7b is expressed in the UB trunk and is essential for the establishment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1089–1094.
Published: 15 March 2015
...Chong Pyo Choe; J. Gage Crump Branching morphogenesis depends on the precise temporal and spatial control of epithelial dynamics. In the vertebrate head, endodermal branches, called pharyngeal pouches, form through the transient stratification, collective migration and reorganization of epithelial...
Includes: Supplementary data