... disorders. With this view in mind, we consider the suitability of animal models for studying these diseases, highlighting human-specific features of human brain development. We conclude by proposing that one such feature, human-specific regulation of neurogenic time, might be key to understanding...

..., effects on neuronal migration were found to result directly from P19 secretion by neural progenitors triggering microglia accumulation within the P19 targeted area. Our findings highlight the crucial role of microglia during brain development and identify P19 as a previously unreported player in the neuro...

... protein. Thus, this technique can be used to interrogate the function of endogenous proteins during early brain development. Brain development involves a myriad of mechanisms and pathways, which rely heavily on proteins operating in defined subcellular compartments, via interactions with other...

... of the brain. Apart from being highly specialized brain phagocytes, microglia modulate the development and functions of neurons and glial cells through both direct and indirect interactions. Thus, recognizing the elements that influence the homeostasis and heterogeneity of microglia in normal brain development...

... ). Polyploidy in the adult Drosophila brain . eLife 9 , e54385 . 10.7554/eLife.54385 Nano , M. and Basto , R. ( 2017 ). Consequences of centrosome dysfunction during brain development . Adv. Exp. Med. Biol. 1002 , 19 - 45 . 10.1007/978-3-319-57127-0_2 Nano , M...

...Jiancheng Liu; Xiwei Wu; Qiang Lu ABSTRACT During mammalian brain development, how different astrocytes are specified from progenitor cells is not well understood. In particular, whether astrocyte progenitor cells (APCs) start as a relatively homogenous population or whether there is early...

...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...

.... Highlighted Article: This study describes a role of TCF7L2 in neuronal differentiation of thalamic glutamatergic neurons at two developmental stages, highlighting its involvement in the postnatal establishment of crucial thalamic electrophysiological features. TCF7L2 Thalamus Brain development...

.../ Highlighted Article: Using experiments and modeling, this study illustrates the importance of not only chemical morphogen gradients, but also mechanical stress distributions, in embryonic development of the cerebral hemispheres. Biomechanics Brain development Finite element model Growth law...

... of this strain demonstrates that p75 NTR regulates multiple aspects of brain development, including cortical progenitor cell survival, and that expression during early neurogenesis is required for appropriate formation of telencephalic structures. * These authors contributed equally to this work...

.... Collectively, our data provide the first evidence for involvement of Ccdc39 in hydrocephalus and suggest that the proper development of medial wall ependymal cilia is crucial for normal mouse brain development. * Authors for correspondence ( Rolf.Stottmann@cchmc.org ; June.Goto@cchmc.org ) Competing...

... , B. , Ryge , J. , Tanaka , E. M. and Simon , A. ( 2010 ). Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain . Development   137 , 4127 - 4134 . 10.1242/dev.055541 Berg , D. A. , Kirkham , M...

...) lineage formation. We show that Barc is required for the generation of neurons during Drosophila brain development by ensuring correct neural progenitor proliferation and differentiation. Barc associates with components of the U2 small nuclear ribonucleoprotein (snRNP) complex, and its depletion causes...

...Mei Yang; Si-Lu Yang; Stephanie Herrlinger; Chen Liang; Monika Dzieciatkowska; Kirk C. Hansen; Ridham Desai; Andras Nagy; Lee Niswander; Eric G. Moss; Jian-Fu Chen Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding...

...@med.kawasaki-m.ac.jp ) Competing interests The authors declare no competing financial interests. 27 2 2014 1 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Atomic force microscopy Elasticity Mechanical property Embryonic tissue Brain development Cerebral...

... and evolutionary origin. * Author for correspondence ( zoltan.molnar@dpag.ox.ac.uk ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Brain development Cortex Evolution Human Neuron...

... ( federico.calegari@crt-dresden.de ) Competing interests statement The authors declare no competing financial interests. 23 4 2013 © 2013. Published by The Company of Biologists Ltd 2013 Lentiviral injection Brain development Gene expression Cre recombination...

... the developing vertebrate central nervous system. However, its conditional deletion at E12.5 in mouse causes few brain developmental problems, with the exception of the postnatal loss of the hippocampal radial glia stem cells and the dentate gyrus. We deleted Sox2 at E9.5 in the telencephalon, using a Bf1-Cre...

...-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. Brain development Mushroom body Neuroblast lineage γ-neuron dachshund ( dac...

... for correspondence ( urbach@uni-mainz.de ) 28 9 2009 © 2009. 2009 Brain development Neuroectodermal regionalization Stem cell specification Drosophila ems/Emx Nkx6 ( HGTX ) vnd/Nkx2 msh ( Drop ) /Msx ind/Gsx The development of the central nervous system in vertebrates...