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Keywords: Brain
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (12): dev198754.
Published: 14 June 2021
...Kouhei Oonuma; Takehiro G. Kusakabe ABSTRACT The Ciona larva has served as a unique model for understanding the development of dopaminergic cells at single-cell resolution owing to the exceptionally small number of neurons in its brain and its fixed cell lineage during embryogenesis. A recent study...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev196147.
Published: 27 May 2021
.... Comparison with mice deficient for integrase interactor 1 ( Ini1 , also known as Smarcb1 ) revealed that the enlarged NR was Brg1 specific and was not caused by a general dysfunction of the SWI/SNF complex. These results suggest a crucial role for Brg1 in NSCs during brain and eye development. * Author...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (6): dev182865.
Published: 16 March 2020
... neurogenesis of the vertebrate habenula depends on tight control of Wnt/β-catenin signaling involving a Wif1-mediated regulatory feedback loop. Habenula Wnt Asymmetry Zebrafish Brain Wif1 Following gastrulation, the developing vertebrate embryo is fine patterned into functional organs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev166207.
Published: 25 September 2018
...Anna E. Hakes; Leo Otsuki; Andrea H. Brand ABSTRACT Neural stem cells must balance symmetric and asymmetric cell divisions to generate a functioning brain of the correct size. In both the developing Drosophila visual system and mammalian cerebral cortex, symmetrically dividing neuroepithelial cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2714–2718.
Published: 1 August 2017
...Magdalena Götz; Sophie Jarriault In early April 2017, over 130 delegates met in Munich, Germany, to discuss the latest research in the development and reprogramming of cells of the nervous system. The conference, which was organised by Abcam and entitled ‘Programming and Reprogramming the Brain...
Journal Articles
Journal: Development
Development (2017) 144 (6): 1025–1034.
Published: 15 March 2017
... and apoptosis, in developing and adult brain. In addition, the RB family is required for self-renewal and survival of human embryonic stem cells (hESCs). Since little is known about the role of RB in human brain development, we investigated its function in cerebral organoids differentiated from gene-edited...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 258–264.
Published: 15 January 2017
... of the sensory vesicle, or brain, originates from ectoderm lineages following a neuro-epidermal binary fate decision. In contrast, a large part of the remaining posterior CNS is generated following neuro-mesodermal binary fate decisions. Here, we address the mechanisms that pattern the anterior brain precursors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2781–2791.
Published: 15 August 2015
...Caroline Badouel; Mark A. Zander; Nicole Liscio; Mazdak Bagherie-Lachidan; Richelle Sopko; Etienne Coyaud; Brian Raught; Freda D. Miller; Helen McNeill Mammalian brain development requires coordination between neural precursor proliferation, differentiation and cellular organization to create...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4489–4499.
Published: 1 December 2014
...Thomas D. Arnold; Colin Niaudet; Mei-Fong Pang; Julie Siegenthaler; Konstantin Gaengel; Bongnam Jung; Gina M. Ferrero; Yoh-suke Mukouyama; Jonas Fuxe; Rosemary Akhurst; Christer Betsholtz; Dean Sheppard; Louis F. Reichardt Vascular development of the central nervous system and blood-brain barrier...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3944–3954.
Published: 15 October 2014
... interests. 15 3 2014 14 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Planar cell polarity Skin Brain Hair follicle Tongue Mouse Complex metazoan animals are replete with structures that exhibit a high degree of spatial order. One type of order...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1453–1464.
Published: 1 April 2014
... the mechanisms linking the activation of an alternative cell death modality and the cell cycle machinery could have a transformative impact on the development of new cancer therapies, but the mechanisms remain completely unknown. We investigated the regulation of alternative cell death in Drosophila larval brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4703–4708.
Published: 1 December 2013
...Tatsuro Ikeda; Terumi Matsuoka; Yutaka Satou The ascidian larval brain and palps (a putative rudimentary placode) are specified by two transcription factor genes, ZicL and FoxC , respectively. FGF9/16/20 induces ZicL expression soon after the bi-potential ancestral cells divide into the brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1159–1169.
Published: 15 March 2013
... in these contexts may aid our understanding of mdDA-related pathologies. The genesis of mdDA neurons involves a number of developmental steps. First, during early development, patterning of the brain induces local regional signaling that specifies the permissive region to induce early mdDA precursors. Thereafter...
Journal Articles
Journal: Development
Development (2012) 139 (18): 3392–3401.
Published: 15 September 2012
... , 1913 – 1920 . Furukubo-Tokunaga K. , Adachi Y. , Kurusu M. , Walldorf U. ( 2009 ). Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster . Fly (Austin) 3 , 263 – 269 . Gibbens Y. Y. , Warren J. T. , Gilbert...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2567–2579.
Published: 15 June 2011
...Helena Acosta; Silvia L. López; Diego R. Revinski; Andrés E. Carrasco The blastula chordin - and noggin -expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2197–2203.
Published: 1 July 2010
... show here that a null mutation in the gene dmrt1 in the ascidian Ciona savignyi results in profound abnormalities in the development of the sensory vesicle (brain), as well as other anterior ectodermal derivatives, including the palps and oral siphon primordium (OSP). Although the phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 43–51.
Published: 1 January 2010
...-renewal of neural progenitors. These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations. Fly brains were dissected, stained and mounted as described in our previous study ( Lee et...
Journal Articles
Journal: Development
Development (2009) 136 (20): 3433–3442.
Published: 15 October 2009
...Abhilasha Kumar; Bruno Bello; Heinrich Reichert The Drosophila central brain is composed of thousands of neurons that derive from approximately 100 neuroblasts per hemisphere. Functional circuits in the brain require precise neuronal wiring and tight control of neuronal numbers. How this accurate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2415–2424.
Published: 15 July 2008
...Robert Lichtneckert; Lionel Nobs; Heinrich Reichert In both insects and mammals, second-order olfactory neurons receive input from olfactory receptor neurons and relay olfactory input to higher brain centers. In Drosophila , the wiring specificity of these olfactory projection neurons (PNs...
Journal Articles
Journal: Development
Development (2008) 135 (3): 513–521.
Published: 1 February 2008
... and motoneuron axon guidance. Here we show that the same two ligands act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain. Blocking this pathway results in the development of larvae...
Includes: Supplementary data