... for the associated developmental and physiological defects are largely unknown. Bone morphogenetic proteins (BMPs) act as highly dynamic complexes to regulate several functions during development. The range and strength of BMP activity depend on interactions with glycosylated protein complexes in the extracellular...

... identified bone morphogenetic protein (BMP) as a candidate myocardium-derived signal required for endocardial differentiation. Chemical and genetic inhibition of BMP signaling at the tailbud stage resulted in severe inhibition of endocardial differentiation while there was little effect on myocardial...

.... , Bhalala O. G. , Kessler J. A. ( 2012 ). The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation . Dev. Neurobiol. 72 , 1068 – 1084 . Bragdon B. , Moseychuk O. , Saldanha S. , King D. , Julian J. , Nohe A. ( 2011 ). Bone...

... ) Competing interests statement The authors declare no competing financial interests. 7 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Bone morphogenetic protein microRNA Vascular endothelial growth factor A Epithelial to mesenchymal transition Outflow tract...

...Ab. Matteen Rafiqi; Chee-Hyurng Park; Chun Wai Kwan; Steffen Lemke; Urs Schmidt-Ott Bone morphogenetic protein (BMP) signaling is an essential factor in dorsoventral patterning of animal embryos but how BMP signaling evolved with fundamental changes in dorsoventral tissue differentiation is unclear...

... of the primitive streak. Formation of an ectopic primitive streak, or streak expansion, has previously been reported in mutants lacking antagonists that target Nodal signaling. Here, we demonstrate that loss-of-function of a major bone morphogenetic protein (BMP) effector, Smad5, results in formation of an ectopic...

... with the core transcriptional network in embryonic stem cells . Cell 133 , 1106 – 1117 . Choi M. , Stottmann R. W. , Yang Y. P. , Meyers E. N. , Klingensmith J. ( 2007 ). The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis . Circ. Res...

...Bing Xu; Cheng Chen; Hui Chen; Song-Guo Zheng; Pablo Bringas, Jr; Min Xu; Xianghong Zhou; Di Chen; Lieve Umans; An Zwijsen; Wei Shi Bone morphogenetic protein 4 (Bmp4) is essential for lung development. To define the intracellular signaling mechanisms by which Bmp4 regulates lung development, BMP...

...Byeong S. Yoon; Robert Pogue; Dmitri A. Ovchinnikov; Isaac Yoshii; Yuji Mishina; Richard R. Behringer; Karen M. Lyons Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture...

...: Department of Biology, Gilmer Hall Rm 253, University of Virginia, PO Box 400328, Charlottesville, VA 22904-4328, USA † Deceased 16 3 2006 © 2006. 2006 Bone morphogenetic protein Proprotein convertase Proteolytic activation Embryonic patterning Cleavage mutant mouse...

... the heart respond to a myocardial-derived signal,undergo EMT, and contribute to cushion mesenchyme. Here, we inactivated bone morphogenetic protein 2 ( Bmp2 ) in the AV myocardium of mice. We show that Bmp2 has three functions in the AV canal: to enhance formation of the cardiac jelly, to induce endocardial...

...Michael A. Bonaguidi; Tammy McGuire; Min Hu; Lixin Kan; Jayshree Samanta; John A. Kessler Bone morphogenetic protein (BMP) and leukemia inhibitory factor (LIF)signaling both promote the differentiation of neural stem/progenitor cells into glial fibrillary acidic protein (GFAP) immunoreactive cells...

...Shawn C. Little; Mary C. Mullins In vertebrates and invertebrates, the bone morphogenetic protein (BMP)signaling pathway patterns cell fates along the dorsoventral (DV) axis. In vertebrates, BMP signaling specifies ventral cell fates, whereas restriction of BMP signaling by extracellular...

..., USA 3 6 2004 © 2004. 2004 Bone morphogenetic protein Bmp Branching morphogenesis Lacrimal gland The lacrimal gland is a structure that develops by branching morphogenesis. Its accessibility and ease of culture combined with the availability of convenient reporter...

...Munehiro Yuhki; Masahisa Yamada; Masako Kawano; Takuji Iwasato; Shigeyoshi Itohara; Hisahiro Yoshida; Masaharu Ogawa; Yuji Mishina Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins...

.... A. ( 1987 ). Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development 99 , 311 -325. Koster, M., Plessow, S., Clement, J. H., Lorenz, A., Tiedemann,H. and Knochel, W. ( 1991 ). Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early...

...Emmanuèle C. Délot; Matthew E. Bahamonde; Manxu Zhao; Karen M. Lyons Bone morphogenetic proteins (BMPs) constitute a family of ∼20 growth factors involved in a tremendous variety of embryonic inductive processes. BMPs elicit dose-dependent effects on patterning during gastrulation and gradients...

...Amir M. Ashique; Katherine Fu; Joy M. Richman Our expression studies of bone morphogenetic proteins (BMPs) and Noggin (a BMP antagonist) in the embryonic chicken face suggested that BMP signals were important for closure of the upper lip or primary palate. We noted that Noggin expression...

... and Nodal proteins probably work cooperatively to induce mesoderm throughout the marginal zone during early Xenopus development. *Author for correspondence (e-mail: harland@socrates.berkeley.edu ) 11 4 2002 © 2002. 2002 BMP Bone morphogenetic protein Derrière Nodal Xnr...

... that generate restricted gene expression along the dorsoventral axis is therefore crucial to understanding the creation of diverse neural cell types. Bone morphogenetic proteins (BMPs) and other transforming growth factor β (TGFβ) proteins are expressed by the dorsal-most cells of the neural tube (the roofplate...