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Keywords: Bone Morphogenetic Protein
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Journal Articles
Journal: Development
Development (2018) 145 (22): dev167338.
Published: 19 November 2018
... for the associated developmental and physiological defects are largely unknown. Bone morphogenetic proteins (BMPs) act as highly dynamic complexes to regulate several functions during development. The range and strength of BMP activity depend on interactions with glycosylated protein complexes in the extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2304–2315.
Published: 1 July 2015
... identified bone morphogenetic protein (BMP) as a candidate myocardium-derived signal required for endocardial differentiation. Chemical and genetic inhibition of BMP signaling at the tailbud stage resulted in severe inhibition of endocardial differentiation while there was little effect on myocardial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4751–4762.
Published: 1 December 2013
... of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Growth differentiation factor 5 Bone morphogenetic protein Dendrite...
Journal Articles
Journal: Development
Development (2013) 140 (16): 3395–3402.
Published: 15 August 2013
... ). A retinoic acid responsive Hoxa3 transgene expressed in embryonic pharyngeal endoderm, cardiac neural crest and a subdomain of the second heart field . PLoS ONE 6 , e27624 . Dudley A. T. , Robertson E. J. ( 1997 ). Overlapping expression domains of bone morphogenetic protein family...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3343–3354.
Published: 15 September 2012
... of the primitive streak. Formation of an ectopic primitive streak, or streak expansion, has previously been reported in mutants lacking antagonists that target Nodal signaling. Here, we demonstrate that loss-of-function of a major bone morphogenetic protein (BMP) effector, Smad5, results in formation of an ectopic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3373–3382.
Published: 15 September 2012
...Ab. Matteen Rafiqi; Chee-Hyurng Park; Chun Wai Kwan; Steffen Lemke; Urs Schmidt-Ott Bone morphogenetic protein (BMP) signaling is an essential factor in dorsoventral patterning of animal embryos but how BMP signaling evolved with fundamental changes in dorsoventral tissue differentiation is unclear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 709–719.
Published: 15 February 2012
... of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA Competing interests statement The authors declare no competing financial interests. 28 11 2011 © 2012. Bone morphogenetic protein Morphogenesis Neural crest Mouse The CNC is a migratory cell population...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 925–935.
Published: 1 March 2011
...Bing Xu; Cheng Chen; Hui Chen; Song-Guo Zheng; Pablo Bringas, Jr; Min Xu; Xianghong Zhou; Di Chen; Lieve Umans; An Zwijsen; Wei Shi Bone morphogenetic protein 4 (Bmp4) is essential for lung development. To define the intracellular signaling mechanisms by which Bmp4 regulates lung development, BMP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4667–4678.
Published: 1 December 2006
...Byeong S. Yoon; Robert Pogue; Dmitri A. Ovchinnikov; Isaac Yoshii; Yuji Mishina; Richard R. Behringer; Karen M. Lyons Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture...
Journal Articles
Journal: Development
Development (2006) 133 (10): 1933–1942.
Published: 15 May 2006
..., these studies provide the first genetic evidence that BMP4 is required for dorsal vertebral fusion and closure of the ventral body wall. Bone morphogenetic proteins (BMPs) are a large subclass of the TGFβsuperfamily that are involved in many aspects of development( Chang et al., 2001 ; Hogan, 1996...
Journal Articles
Journal: Development
Development (2005) 132 (24): 5601–5611.
Published: 15 December 2005
... the heart respond to a myocardial-derived signal,undergo EMT, and contribute to cushion mesenchyme. Here, we inactivated bone morphogenetic protein 2 ( Bmp2 ) in the AV myocardium of mice. We show that Bmp2 has three functions in the AV canal: to enhance formation of the cardiac jelly, to induce endocardial...
Journal Articles
Journal: Development
Development (2005) 132 (24): 5503–5514.
Published: 15 December 2005
...Michael A. Bonaguidi; Tammy McGuire; Min Hu; Lixin Kan; Jayshree Samanta; John A. Kessler Bone morphogenetic protein (BMP) and leukemia inhibitory factor (LIF)signaling both promote the differentiation of neural stem/progenitor cells into glial fibrillary acidic protein (GFAP) immunoreactive cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5825–5835.
Published: 1 December 2004
...Shawn C. Little; Mary C. Mullins In vertebrates and invertebrates, the bone morphogenetic protein (BMP)signaling pathway patterns cell fates along the dorsoventral (DV) axis. In vertebrates, BMP signaling specifies ventral cell fates, whereas restriction of BMP signaling by extracellular...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4155–4165.
Published: 1 September 2004
... normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122 , 1693 -1702. Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B. L. ( 1997 ). Fibroblast growth factor 10 (FGF10) and branching...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1825–1833.
Published: 15 April 2004
...Munehiro Yuhki; Masahisa Yamada; Masako Kawano; Takuji Iwasato; Shigeyoshi Itohara; Hisahiro Yoshida; Masaharu Ogawa; Yuji Mishina Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2071–2081.
Published: 15 May 2003
... is essential in the establishment of the neural induction response. In vertebrate early development, bone morphogenetic protein (BMP) signaling stimulates epidermal induction of undifferentiated cells in the presumptive ectoderm region and inhibits neural induction( Hemmati-Brivanlou and Melton,1997...
Journal Articles
Journal: Development
Development (2003) 130 (1): 209–220.
Published: 1 January 2003
...Emmanuèle C. Délot; Matthew E. Bahamonde; Manxu Zhao; Karen M. Lyons Bone morphogenetic proteins (BMPs) constitute a family of ∼20 growth factors involved in a tremendous variety of embryonic inductive processes. BMPs elicit dose-dependent effects on patterning during gastrulation and gradients...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4647–4660.
Published: 1 October 2002
...Amir M. Ashique; Katherine Fu; Joy M. Richman Our expression studies of bone morphogenetic proteins (BMPs) and Noggin (a BMP antagonist) in the embryonic chicken face suggested that BMP signals were important for closure of the upper lip or primary palate. We noted that Noggin expression...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3089–3103.
Published: 1 July 2002
... and Nodal proteins probably work cooperatively to induce mesoderm throughout the marginal zone during early Xenopus development. *Author for correspondence (e-mail: harland@socrates.berkeley.edu ) 11 4 2002 © 2002. 2002 BMP Bone morphogenetic protein Derrière Nodal Xnr...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2459–2472.
Published: 15 May 2002
... that generate restricted gene expression along the dorsoventral axis is therefore crucial to understanding the creation of diverse neural cell types. Bone morphogenetic proteins (BMPs) and other transforming growth factor β (TGFβ) proteins are expressed by the dorsal-most cells of the neural tube (the roofplate...