...Jason W. Millington; Puja Biswas; Charlotte Chao; Yi Han Xia; Lianna W. Wat; George P. Brownrigg; Ziwei Sun; Paige J. Basner-Collins; Ramon I. Klein Geltink; Elizabeth J. Rideout ABSTRACT In Drosophila , changes to dietary protein elicit different body size responses between the sexes. Whether...

..., the position of QR descendants depends on body size, which we varied by changing maternal age or using body size mutants. Using a mathematical model, we show that body size variation is partially compensated for. Applying environmental perturbations, we find that the variance in final position increased...

...Eudald Pascual-Carreras; Marta Marin-Barba; Carlos Herrera-Úbeda; Daniel Font-Martín; Kay Eckelt; Nidia de Sousa; Jordi García-Fernández; Emili Saló; Teresa Adell ABSTRACT Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation...

...Sarah D. Neuman; Arash Bashirullah ABSTRACT All animals must coordinate growth rate and timing of maturation to reach the appropriate final size. Here, we describe hobbit , a novel and conserved gene identified in a forward genetic screen for Drosophila animals with small body size. hobbit...

... molecule (RGM) family of proteins in C. elegans , and is crucial in regulating body size and mesoderm development. Using a combination of molecular genetic and biochemical analyses, we demonstrate that DRAG-1 is a membrane-associated protein that functions at the ligand-receptor level to modulate the Sma...

... expression and dMyc transcriptional activity. Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions. In S2R+ cells, Luciferase activity of CG4364 and CG5033 reporters was detected...

... for generating different body sizes in the sexes; in Drosophila , females are larger and this difference is controlled by Sxl . Consistent with this proposal, discs expressing ectopic Sxl show an increase in growth. In keeping with the idea of the involvement of a signaling system, this growth effect by Sxl...

...Jianjun Wang; William A. Mohler; Cathy Savage-Dunn TGF-β signaling in the nematode Caenorhabditis elegans plays multiple roles in the development of the animal. The Sma/Mab pathway controls body size, male tail sensory ray identity and spicule formation. Three Smad genes, sma-2 , sma-3 and sma-4...

...Naoharu Watanabe; Yasuko Nagamatsu; Keiko Gengyo-Ando; Shohei Mitani; Yasumi Ohshima We have analyzed the sma-5(n678) mutant in C. elegans to elucidate mechanisms controlling body size. The sma-5 mutant is very small, grows slowly and its intestinal granules look abnormal. We found a 15 kb deletion...

...Jun Liang; Robyn Lints; Marisa L. Foehr; Rafal Tokarz; Ling Yu; Scott W. Emmons; Jun Liu; Cathy Savage-Dunn In Caenorhabditis elegans , the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9 , that encodes the C...

..., whereas cell numbers are not. Experiments on genetic interaction suggest that the cGMP-EGL-4 signaling pathway represses body size and lifespan through DBL-1/TGF-β and insulin pathways, respectively. To identify the egl-4 gene, we mapped egl-4 ( ks16 ) using SNPs to a region between cosmids K07A9...

...Jianjun Wang; Rafal Tokarz; Cathy Savage-Dunn In C. elegans , a TGFβ-related signaling pathway regulates body size. Loss of function of the signaling ligand ( dbl-1 ),receptors ( daf-4 and sma-6 ) or Smads ( sma-2, sma-3 and sma-4 ) results in viable, but smaller animals because of a reduction...