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Keywords: Bmp4
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Journal Articles
Journal: Development
Development (2023) 150 (10): dev201450.
Published: 22 May 2023
... as an indispensable heart inducer. A detailed analysis of the role of Bmp4 and its effectors Smad1/5, however, was still missing. We show that Bmp4 induces cardiac mesoderm formation in murine embryonic stem cells in vitro . Bmp4 first activates Wnt3 and upregulates Nodal . pSmad1/5 and the WNT effector Tcf3 form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201048.
Published: 23 March 2023
... in ureter specification by generating a mesenchymal domain around the distal ureteric bud where SHH and BMP4 signaling can occur. We performed whole-mount RNA in situ hybridizations following a standard procedure with digoxigenin-labeled antisense riboprobes ( Wilkinson and Nieto, 1993 ). Stained...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200767.
Published: 12 September 2022
.... We have recently shown that epithelial FGFR2 signaling regulates stratification and differentiation of the epithelial compartment by enhancing epithelial Shh expression, and mesenchymal SHH and BMP4 activity. Here, we show that FGFR1 and FGFR2 expression in the mesenchymal primordium impinges...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
... negatively on epithelial expression of Shh and its mesenchymal effector gene Bmp4 . Activation of SHH or BMP4 signaling largely rescued the cellular defects of mutant ureters in explant cultures. Conversely, inhibition of SHH or BMP signaling in wild-type ureters recapitulated the mutant phenotype in a dose...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (4): dev161075.
Published: 23 February 2018
..., it binds a gene cohort involved in primitive streak formation at gastrulation, including NODAL , BMP4 and WNT3 . Comparing TCF7L1-bound sites with those bound by the WNT signaling effector β-catenin indicates that TCF7L1 acts largely on the WNT signaling pathway. TCF7L1 overlaps less with the pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1296–1306.
Published: 1 April 2017
... and function were explored in early porcine embryos. Notably, siRNA-mediated gene knockdown and lentivirus-mediated TE-specific gene regulation demonstrated that CDX2 is essential for the maintenance of blastocyst integrity by regulating the BMP4-mediated blastocyst niche and classic protein kinase C (PKC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
... cell death that includes mesodermal progenitor cells that have begun to precociously differentiate into cartilage cells. We propose that PRMT5 maintains progenitor cells through its regulation of Bmp4 . Intriguingly, adult and embryonic stem cells also require PRMT5 for maintaining pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3383–3393.
Published: 1 October 2015
... stratification. We also discovered that Bmp4 is upregulated in the absence of β-catenin in keratocytes, which further triggers ERK1/2 (Mapk3/1) and Smad1/5 phosphorylation and enhances transcription factor p63 (Trp63) expression in mouse corneal basal epithelial cells and in a human corneal epithelial cell line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... the BMP4 pathway is required for their differentiation. These findings establish an alternative model for patella development and provide the mechanical and molecular mechanisms that underlie this process. More broadly, our finding that activation of a joint formation program can be used to switch between...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (22): 4533–4543.
Published: 15 November 2013
... a transient region in the anterior-proximal side of the embryo at E7.0 that possesses the ability to become neural or epidermal ectoderm in response to the absence or presence of BMP4, respectively. Furthermore, we demonstrated that inhibition of Nodal signaling could direct the pluripotent E6.5 epiblast...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (13): 2680–2690.
Published: 1 July 2013
... that a distinct pool of Sox9 - and Scx -positive progenitors forms these superstructures. We demonstrate that TGFβ signaling is necessary for the specification of bone eminence progenitors, whereas the SCX/BMP4 pathway is required for the differentiation of these progenitors to eminence-forming cells. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 423–432.
Published: 15 January 2013
...Shihai Jia; Jing Zhou; Yang Gao; Jin-A Baek; James F. Martin; Yu Lan; Rulang Jiang Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas all tooth germs were arrested at the bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4499–4509.
Published: 15 October 2011
... ( cspg2, fibulin 1, tbx2b, bmp4 ) is expanded and endocardial cells along the extended tube-like structure exhibit characteristics of AV cells ( has2, notch1b and Alcam expression, cuboidal cell shape). Inhibition of has2 in npnt morphants rescues the endocardial, but not the myocardial, expansion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3169–3177.
Published: 1 August 2011
... FGF FGF receptor WNT β-Catenin BMP4 Noggin Mouse Lung development is governed by complex interactions between embryonic lung endoderm, mesoderm and mesothelium. During the pseudoglandular stage of lung development [embryonic day (E) 9.5-16 in the mouse], fibroblast growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
... in the Notch-interaction domain of Jag2 presented a variety of severe dental abnormalities. In molars, the crown morphology was misshapen, with additional cusps being formed. This was due to alterations in the enamel knot, an epithelial signalling structure involved in molar crown morphogenesis, in which Bmp4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2095–2105.
Published: 1 July 2010
... differentiation. However, it remains unclear when and how BMP signaling executes those different functions during neural commitment. Here, we show that a BMP4-sensitive window exists during ESC neural differentiation. Cells at this specific period correspond to the egg cylinder stage epiblast and can...
Includes: Supplementary data