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Keywords: Bmp signaling
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev199890.
Published: 4 February 2022
...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev196519.
Published: 1 July 2021
... pSer-19-mediated MLC2 contractility. The compressive stress acts through BMP signaling to increase cell proliferation and decrease cell contractility, and MEK-ERK is essential for both compressive stress and BMP mediation of compaction. We further showed that the effects of osmotic stress are conserved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
... is spatially patterned by WNT and BMP signaling. BMP signaling Ectoderm development WNT signaling Human embryonic stem cells Self-organization The human ectodermal germ layer arises as a spatially organized epithelium composed of progenitors of the neural plate, neural crest, placodes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev164103.
Published: 21 March 2019
... erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1 ). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous , another fish, and in the mouse genome. Both genes also inhibit BMP signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev166017.
Published: 15 February 2019
.... ( 1930 ). Regenerationsstudien an Anneliden und Branchiostoma lanceolatum (Pallas) . Rev. Suisse. Zool.   37 , 343 - 352 . Rajaram , S. , Patel , S. , Uggini , G. K. , Desai , I. and Balakrishnan , S. ( 2017 ). BMP signaling regulates the skeletal and connective tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev164160.
Published: 3 December 2018
... estimation of the expression of Dppa2 , Otx2 and Utf1 and BMP signaling-related genes in Setdb1 KD cell aggregates at day 2 after transfection. Expression levels were determined by RT-qPCR, and relative expression levels in Setdb1 KD cell aggregates compared with those in control KD cell aggregates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev166710.
Published: 26 October 2018
... regulates BMP signaling. From these results, we conclude that Fam46a is required for PPE formation via the positive regulation of BMP signaling. Our study provides a new mechanism of ectodermal patterning via cell-autonomous regulation of BMP signaling in the PPE. * Present address: National...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154047.
Published: 3 January 2018
.... and Dura , J.-M. ( 2012 ). Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-beta/BMP signaling and orphan nuclear receptors . PLoS ONE   7 , e40255 . 10.1371/journal.pone.0040255 Brooks , A. N. , Duff , M. O. , May , G. , Yang , L...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2982–2993.
Published: 15 August 2017
... under the action of the segmentation clock. The signals responsible for tailbud mesoderm progenitor pool maintenance during axial elongation are still elusive. Here, we show that Bmp signaling is sufficient to activate the entire mesoderm progenitor gene signature in primary cultures of caudal mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2737–2747.
Published: 1 August 2017
... of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here, we demonstrate that postnatal satellite cells express components of the bone morphogenetic protein (BMP) signaling machinery. Overexpression of noggin in postnatal mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 3002–3011.
Published: 15 August 2016
... affecting EE tissue specification or maintenance. These macroevolutionary changes in function between Tribolium and Drosophila are accompanied by regulatory network changes, where BMP signaling and possibly the transcription factor Hindsight are downstream mediators. We propose that the ancestral role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 2000–2011.
Published: 1 June 2016
..., including the Bone morphogenetic protein (Bmp) pathway. However, the role of Bmp signaling in pouch morphogenesis is poorly understood. Using genetic and chemical inhibitor approaches, we show that pouch morphogenesis requires Bmp signaling from 10-18 h post-fertilization, immediately following gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 764–773.
Published: 1 March 2016
...-renewal and differentiation in a clonal organoid (tracheosphere) assay. This revealed that inhibitors of the canonical BMP signaling pathway promote proliferation but do not affect lineage choice, whereas exogenous Bmp4 inhibits proliferation and differentiation. We therefore followed changes in BMP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1767–1776.
Published: 15 May 2015
... in cardiomyocyte numbers. Cell-tracing experiments, using photoconvertable fluorescent proteins and genetic labeling, demonstrate that Gpc4 ‘Knypek’ is required for specification of cardiac progenitor cells and their differentiation into cardiomyocytes. Mechanistically, we show that Bmp signaling is enhanced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 465–476.
Published: 1 February 2015
... the specificity of cell fate control by distinctive Mediator subunits. Gene profiling revealed that Med23 depletion attenuated BMP signaling in ESCs. Mechanistically, MED23 modulated Bmp4 expression by controlling the activity of ETS1, which is involved in Bmp4 promoter-enhancer communication. Interestingly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 436–447.
Published: 15 January 2014
...Mikolaj Sulkowski; Young-Jun Kim; Mihaela Serpe Effective communication between pre- and postsynaptic compartments is required for proper synapse development and function. At the Drosophila neuromuscular junction (NMJ), a retrograde BMP signal functions to promote synapse growth, stability...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4070–4080.
Published: 1 October 2013
...Chenxi Tian; Herong Shi; Shan Xiong; Fenghua Hu; Wen-Cheng Xiong; Jun Liu The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2181–2189.
Published: 15 May 2013
.../FMRFa neuron, promoting its differentiation through the initiation of BMP signaling. Our findings indicate a pleiotropic function of Klu in Ap cluster specification in general and particularly in Ap4 neuron differentiation, indicating that Klu is a multitasking transcription factor. Finally, our studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 530–540.
Published: 1 February 2013
... that are shared between normal stem cells and cancers. For example, analogous to the function of CycE in stimulating BMP signaling in Drosophila GSCs, CycE may contribute to the stem cell-like potential of cancers to generate new cells, perhaps by boosting the signaling activity of key tumorigenic pathways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4250–4260.
Published: 15 November 2012
...Jean-Denis Bénazet; Emanuele Pignatti; Ashleigh Nugent; Erkan Unal; Frédéric Laurent; Rolf Zeller SMAD4 is an essential mediator of canonical TGFβ/BMP signal transduction and we inactivated Smad4 in mouse limb buds from early stages onward to study its functions in the mesenchyme. While this Smad4...
Includes: Multimedia, Supplementary data