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Keywords: Blood-brain barrier
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev200340.
Published: 12 May 2022
... and barrier development, also functions as an integral unit in limb development. Wnt signaling Blood-brain barrier Limb development Mouse Howard Hughes Medical Institute Johns Hopkins University The vertebrate limb has been one of the premier systems...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev185140.
Published: 24 August 2020
... blood-brain barrier (BBB) that is necessary for neuronal survival and activity. Although Wnt/β-catenin signaling is essential for BBB development, its downstream targets within the neurovasculature remain poorly understood. To identify targets of Wnt/β-catenin signaling underlying BBB maturation, we...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (9): dev182279.
Published: 1 May 2020
.... , Sabbagh , M. , Wosik , K. , Bourbonniere , L. , Bernard , M. , et al. ( 2011 ). The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence . Science   334 , 1727 - 1731 . 10.1126/science.1206936 Armulik , A. , Genové , G. , Mäe , M...
Journal Articles
Journal: Development
Development (2019) 146 (23): dev177790.
Published: 2 December 2019
... surface marker is suppressed during differentiation of the blood brain barrier . Dev. Dyn.   202 , 325 - 332 . 10.1002/aja.1002020402 Hamilton , B. J. , Tse , D. and Stan , R. V. ( 2019 ). Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev170910.
Published: 8 July 2019
... differential functional properties. This was confirmed by differential calcium signaling as well as effects on neurite growth and blood-brain barrier formation. Distinct transcriptional profiles and functional properties of human astrocytes generated from regionally specified neural progenitors under the same...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (15): dev164111.
Published: 13 August 2018
... the Drosophila blood-brain barrier. During larval growth, the perineurial glia proliferate, whereas the subperineurial glia expand enormously and become polyploid. Here, we show that the level of ploidy in the subperineurial glia is controlled by the N-terminal asparagine amidohydrolase homolog Öbek, and high...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (1): 8–11.
Published: 1 January 2017
... protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier . Proc. Natl. Acad. Sci. USA   108 , 5759 - 5764 . 10.1073/pnas.1017192108 de Almeida , G. M. , Yamamoto , M. , Morioka , Y. , Ogawa , S. , Matsuzaki , T...
Journal Articles
Journal: Development
Development (2016) 143 (1): 147–159.
Published: 1 January 2016
...; Brant M. Weinstein; Jesús Torres-Vázquez The cerebral vasculature provides the massive blood supply that the brain needs to grow and survive. By acquiring distinctive cellular and molecular characteristics it becomes the blood-brain barrier (BBB), a selectively permeable and protective interface between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3046–3057.
Published: 1 September 2015
... attributed. Summary: Two tetraspan membrane proteins, Pasiflora1 and 2, are essential components of the Drosophila septate junction required for epithelial and blood-brain barrier integrity. Septate junction Blood-brain barrier Trachea Drosophila Epithelia The generation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 307–317.
Published: 15 January 2014
... ill defined. Here, we report an investigation of the Notch3 receptor using zebrafish as a model system. We show that zebrafish brain pericytes express notch3 and that notch3 mutant zebrafish have a deficit of brain pericytes and impaired blood-brain barrier function. Conditional loss- and gain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1765–1776.
Published: 15 May 2012
...Floriano Rodrigues; Leila Thuma; Christian Klämbt The differentiation of the blood-brain barrier (BBB) is an essential process in the development of a complex nervous system and depends on alternative splicing. In the fly BBB, glial cells establish intensive septate junctions that require the cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2427–2437.
Published: 15 July 2010
... . Stork T. , Engelen D. , Krudewig A. , Silies M. , Bainton R. J. , Klambt C. ( 2008 ). Organization and function of the blood-brain barrier in Drosophila . J. Neurosci. 28 , 587 - 597 . Sturge J. , Wienke D. , East L. , Jones G. E. , Isacke...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2199–2209.
Published: 1 July 2009
... junctions,which are essential for axonal insulation and propagation of action potentials. In insects, the epithelial and neural SJs share many components, so our observation that bou is not required for blood-brain barrier maintenance in the ventral nerve cord came as a surprise, revealing...
Includes: Supplementary data