... the adult stem cell marker Lgr5 , and generate both hepatocyte and cholangiocyte progeny that persist for the lifespan of the mouse. Combining lineage tracing and scRNA-seq, we show that Lgr5 marks E9.5-E10.0 bipotent liver progenitors residing at the apex of a hepatoblast hierarchy. Furthermore, isolated...

... the gel was compared with itself. In the present study, we have examined bipotentiality of fetal liver cells expressing cholangiocyte markers, so-called CMP-FLEC. Our rationale was derived from previous studies showing that oval cells of biliary origin possess bipotent or multipotent...