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Keywords: Bicoid
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Journal Articles
Journal: Development
Development (2015) 142 (23): 3996–4009.
Published: 1 December 2015
... , S. , Sandler , O. , Sberro , H. , Shnider , S. , Schejter , E. , Shilo , B.-Z. and Barkai , N. ( 2007 ). Pre-steady-state decoding of the Bicoid morphogen gradient . PLoS Biol.   5 , e46 . 10.1371/journal.pbio.0050046 Bergsland , M. , Ramsköld , D...
Journal Articles
Journal: Development
Development (2015) 142 (21): 3781–3790.
Published: 1 November 2015
... their precise timing may impact embryonic development. Here we perturb the timing of the shutdown of Bicoid (Bcd)-dependent hunchback ( hb ) transcription in the embryo through the use of a Bcd mutant that has heightened activating potency. A delayed shutdown specifically increases Bcd-activated hb levels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 587–596.
Published: 1 February 2015
... network in Drosophila melanogaster embryos by depleting a key maternal input, bicoid ( bcd ), and measuring gene expression patterns of the network at cellular resolution. This method results in a gene expression atlas containing the levels of mRNA or protein expression of 13 core patterning genes over...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 124–135.
Published: 1 January 2014
... interrogations of the properties of morphogen gradients that instruct patterning. Recent studies of the Drosophila morphogen gradient Bicoid (Bcd), which is required for anterior-posterior (AP) patterning in the early embryo, have uncovered two distinct ways of scaling. Whereas between-species scaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2857–2862.
Published: 1 September 2010
.... For morphogens that function as transcription factors, the final distribution can be heavily influenced by the number of nuclear binding sites. Here, we have addressed the role of the increasing number of nuclei during the formation of the Bicoid gradient in embryos of Drosophila melanogaster . Deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2253–2264.
Published: 15 July 2010
...Oliver Grimm; Mathieu Coppey; Eric Wieschaus Morphogen gradients provide embryonic tissues with positional information by inducing target genes at different concentration thresholds and thus at different positions. The Bicoid morphogen gradient in Drosophila melanogaster embryos has recently been...
Journal Articles
Journal: Development
Development (2010) 137 (11): 1853–1862.
Published: 1 June 2010
...Kay Kotkamp; Martin Klingler; Michael Schoppmeier In the short-germ beetle Tribolium castaneum , the head gap gene orthodenticle ( Tc-otd ) has been proposed to functionally substitute for bicoid , the anterior morphogen unique to higher dipterans. In this study we reanalyzed the function of Tc-otd...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1709–1719.
Published: 15 May 2010
... activation in Drosophila , we used loss- and gain-of-function experiments in the hover fly Episyrphus balteatus (Syrphidae) to address the question of how the maternal regulation of gap genes evolved. We find that, in Episyrphus , a highly diverged bicoid ortholog is solely responsible for the AP polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 169–176.
Published: 1 January 2010
...Timothy T. Weil; Despina Xanthakis; Richard Parton; Ian Dobbie; Catherine Rabouille; Elizabeth R. Gavis; Ilan Davis Localization of bicoid mRNA to the anterior of the Drosophila oocyte is essential for patterning the anteroposterior body axis in the early embryo. bicoid mRNA localizes in a complex...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 605–614.
Published: 15 February 2009
...Alexander Spirov; Khalid Fahmy; Martina Schneider; Erich Frei; Markus Noll; Stefan Baumgartner The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves...
Journal Articles
Journal: Development
Development (2009) 136 (1): 117–127.
Published: 1 January 2009
... the issue of whether such differences co-evolve with the mechanisms that establish anteroposterior (AP) polarity of the embryo. AP polarity of the Drosophila embryo depends on bicoid , which is necessary and sufficient to determine the anterior body plan. Orthologs of bicoid have been identified in various...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (24): 5343–5352.
Published: 15 December 2005
... unknown. In many developmental mutants in Drosophila , large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (23): 5897–5907.
Published: 1 December 2004
...Veit Riechmann; Anne Ephrussi The Ser/Thr kinase Par-1 is required for cell polarisation in diverse organisms such as yeast, worms, flies and mammals. During Drosophila oogenesis, Par-1 is required for several polarisation events, including localisation of the anterior determinant bicoid...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4201–4215.
Published: 1 September 2003
...Sophie G. Martin; Vincent Leclerc; Katie Smith-Litière; Daniel St Johnston The anteroposterior axis of Drosophila is defined during oogenesis, when the polarisation of the oocyte microtubule cytoskeleton directs the localisation of bicoid and oskar mRNAs to the anterior and posterior poles...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (7): 1669–1680.
Published: 1 April 2002
...Chen Zhao; Allen York; Fan Yang; David J. Forsthoefel; Vrushank Dave; Dechen Fu; Dongyi Zhang; Maria S. Corado; Stephen Small; Mark A. Seeger; Jun Ma The Drosophila morphogenetic protein Bicoid (Bcd) is a homeodomain-containing activator that stimulates the expression of target genes during early...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5129–5138.
Published: 15 December 2001
... the control of the AP patterning system and require bicoid activity. The anterior-most domain is a region of large yolk stalk diameters and corresponds to the region of decreased nuclear densities observed during syncytial stages. The middle domain shows smaller yolk stalk diameters and more rapid...
Journal Articles
Journal: Development
Development (1994) 1994 (Supplement): 187–191.
Published: 1 January 1994
... insects, correlations between oogenesis and embryonic pattern formation, the universality or otherwise of bicoid as the anterior morphogen, novel functions in the insect Hox complex, the formal asymmetry between evolution and decay of complex gene networks, novel regulatory interactions as the main cause...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 13–19.
Published: 1 April 1989
...Daniel St. Johnston; Wolfgang Driever; Thomas Berleth; Sibyll Richstein; Christiane Nüsslein-Volhard The anterior region of the Drosophila embryonic pattern is determined by a gradient of the bicoid (bcd) protein. The correct formation of this gradient requires the localization of bcd RNA...