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Keywords: BMP antagonismClose
Development (2004) 131 (14): 3401–3410.
Published: 15 July 2004
... defects. In early limb buds, mesenchymal Grem1 is required to establish a functional apical ectodermal ridge and the epithelial-mesenchymal feedback signaling that propagates the sonic hedgehog morphogen. Furthermore, Grem1 -mediated BMP antagonism is essential to induce metanephric kidney development...