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Keywords: BMP
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev200182.
Published: 3 December 2021
...Julie Gamart; Iros Barozzi; Frédéric Laurent; Robert Reinhardt; Laurène Ramos Martins; Thomas Oberholzer; Axel Visel; Rolf Zeller; Aimée Zuniga ABSTRACT SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev195883.
Published: 12 July 2021
...Mari Ichinose; Nobumi Suzuki; Tongtong Wang; Hiroki Kobayashi; Laura Vrbanac; Jia Q. Ng; Josephine A. Wright; Tamsin R. M. Lannagan; Krystyna A. Gieniec; Martin Lewis; Ryota Ando; Atsushi Enomoto; Simon Koblar; Paul Thomas; Daniel L. Worthley; Susan L. Woods ABSTRACT Bone morphogenetic protein (BMP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
..., BMPR1A or BMPR1B to transduce BMP signals. In response to BMP signals, BMPR2A/BMPR2B may interact with ACVR1, ACVRL1, BMPR1A or BMPR1B. AMHR2 may interact with ACVR1, BMPR1A or BMPR1B to transduce AMH signal. In most cases, type II and type I receptors form homodimers; however, ACVRL1-TGFBR1, ACVR1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
... expression is significantly perturbed in the mutant are known to be crucially involved in hindbrain patterning, and include components of the BMP ( Watanabe et al., 2012 ) and canonical Wnt signaling pathways. The gene encoding the extracellular BMP antagonist Grem1 is robustly upregulated in the mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev189373.
Published: 23 September 2020
...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
... tissues mediated by Shh depletion. Two candidates are BMP, which acts antagonistically to Shh ( Dessaud et al., 2007 ; Ericson et al., 1997a ; McMahon et al., 1998 ), and retinoic acid from the somite that affects NT development ( Diez del Corral et al., 2003 ; Wilson et al., 2003 ). To this end...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184036.
Published: 27 April 2020
... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish The term ‘cardiac looping’ defines a morphogenetic process during vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 4 July 2019
.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev172619.
Published: 8 May 2019
.... Therefore, we conclude that early stages of myocardial differentiation rely on endocardial paracrine signaling mediated in part by Bmp2. Our findings provide novel insight into early endocardial-myocardial interactions that can be explored to promote early myocardial development and growth. Bmp ESC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... anatomical and ultimately functional variation during sesamoid bone development. Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et al., 2017 ; Bizarro, 1921...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166876.
Published: 28 November 2018
... in mutants that have lost the energy sensor AMP-activated protein kinase (AMPK) or the insulin/IGF-1 signaling (IIS) negative regulator DAF-18/PTEN. We report that DBL-1/BMP works upstream of IIS to promote agonistic insulin-like peptides during L1 arrest. However, the abnormal Q cell divisions that occur...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163519.
Published: 10 August 2018
... descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. Previous studies have...
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... in the control of initial DV polarity by promoting the development of the ventral center and by destabilizing transcriptionally active β-catenin. Notch β-catenin Dorsoventral development BMP Wnt8a Ventx Xenopus Zebrafish During the past two decades, many studies, mostly performed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
...Mei-I Chung; Melissa Bujnis; Christina E. Barkauskas; Yoshihiko Kobayashi; Brigid L. M. Hogan ABSTRACT The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
.... , Xu , M. , Feldman , G. J. , Fenstermacher , D. A. , Cho , T.-J. , Choi , I. H. , Connor , J. M. , Delai , P. , Glaser , D. L. , LeMerrer , M. , et al. ( 2006 ). A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia...
Journal Articles
Journal: Development
Development (2017) 144 (15): 2771–2783.
Published: 1 August 2017
... transients modulate the temporal dynamics of Dpp presentation in developmental BMP signaling, impacting the downstream transcriptional response and tissue morphogenesis. Fly wing morphogenesis Dpp BMP Bioelectric signaling KCNJ2 Drosophila melanogaster Dominant-negative mutations...
Includes: Supplementary data