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Development (2010) 137 (23): 4005–4015.
Published: 1 December 2010
... specifically in the trigeminal nerve and in spinal motor and sensory neurons in a Brain-derived neurotrophin factor (BDNF)-dependent manner. Knockdown of Spry3 expression causes an excess of axonal branching in spinal cord motoneurons in vivo. Furthermore, Spry3 inhibits the ability of BDNF to induce filopodia...
Includes: Multimedia, Supplementary data
Development (2009) 136 (20): 3405–3412.
Published: 15 October 2009
... of a developmental switch in the intracellular signalling network required for an identical cellular response to the same extracellular signal in the same cell type. We show that although NF-κB signalling is required for BDNF-promoted neurite growth from both foetal and postnatal mouse sensory neurons...
Development (2009) 136 (9): 1519–1528.
Published: 1 May 2009
... to show that the neural crest does not supply cells to taste buds, either embryonically or postnatally, thus ruling out a mesenchymal contribution to taste buds. Finally, using Bdnf null mice, which lose neurons that innervate taste buds, we demonstrate that Shh-expressing taste bud progenitors...
Includes: Supplementary data
Development (2007) 134 (24): 4369–4380.
Published: 15 December 2007
... in embryonic precursor cell proliferation both in culture and in vivo. Inhibition of TrkB/C also caused a delay in the generation of neurons, but not astrocytes, and ultimately perturbed the postnatal localization of cortical neurons in vivo. Conversely, overexpression of BDNF in cortical precursors in vivo...
Denise Greenwood, Daniel J. Jagger, Lin-Chien Huang, Noriyuki Hoya, Peter R. Thorne, Scott S. Wildman, Brian F. King, Kwang Pak, Allen F. Ryan, Gary D. Housley
Development (2007) 134 (7): 1407–1417.
Published: 1 April 2007
..., activation of the P2X receptor signaling pathway by ATPγS or α,βMeATP inhibited BDNF-induced neurite outgrowth and branching. These findings indicate that P2X receptor signaling provides a mechanism for inhibiting neurotrophin support of SGN neurites when synaptic reorganization is occurring in the cochlea...
Development (2005) 132 (14): 3231–3242.
Published: 15 July 2005
... properties. Preadsorption of CM Cerebellum with antisera against candidate cytokines showed that TGFβ2 and BDNF could account for the major part of the anti-proliferative and pro-differentiating activities, an interpretation strengthened by studies involving treatment with purified TGFβ2 and BDNF...
Development (2005) 132 (7): 1713–1726.
Published: 1 April 2005
... contributed equally to this work † Present address: Lab Anatomia patologica-genetica, Hospital Arnau de Vilanova, Av Rovira Rourre, 80, 25198 Lleida, Spain 5 1 2005 ©2005. 2005 NF-κB Axon Dendrite BDNF Pyramidal neuron Sensory neuron Mouse Nuclear factor-κB (NF-κB...
Thomas Schimmang, Justin Tan, Marcus Müller, Ulrike Zimmermann, Karin Rohbock, Iris Köpschall, Annette Limberger, Liliana Minichiello, Marlies Knipper
Development (2003) 130 (19): 4741–4750.
Published: 1 October 2003
... of the mature cochlea is currently unknown. Here, we have analysed the consequences of a lack of the TrkB receptor and its ligand, the neurotrophin brain-derived neurotrophic factor (Bdnf), in the late postnatal or adult cochlea using mouse mutants. During early postnatal development, mutant animals show a lack...
Pontus C. Holm, Francisco J. Rodríguez, Adelheid Kresse, Josep M. Canals, Inmaculada Silos-Santiago, Ernest Arenas
Development (2003) 130 (15): 3535–3545.
Published: 1 August 2003
... BDNF NT4 NT3 GDNF Locus coeruleus Neurotrophins Rat primary cultures More than half of central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Innervation from LC reaches target regions throughout the entire brain and regulates a variety of functions, such as mood...
Karin Agerman, Jens Hjerling-Leffler, Marie Pierre Blanchard, Eric Scarfone, Barbara Canlon, Christopher Nosrat, Patrik Ernfors
Development (2003) 130 (8): 1479–1491.
Published: 15 April 2003
.... Neurotrophin specificity has been attributed to the selective expression of the Trk tyrosine kinase receptors in different neuronal subpopulations. However, despite overlapping expression of TrkB and TrkC in many sensory ganglia, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) null mutant...
Fernando Aguado, Maria A. Carmona, Esther Pozas, Agustín Aguiló, Francisco J. Martínez-Guijarro, Soledad Alcantara, Victor Borrell, Rafael Yuste, Carlos F. Ibañez, Eduardo Soriano
Development (2003) 130 (7): 1267–1280.
Published: 1 April 2003
..., including migration, neural differentiation and formation and refinement of connections. The mechanisms regulating spontaneous activity are not known. By using transgenic embryos that overexpress BDNF under the control of the nestin promoter, we show here that BDNF controls the emergence and robustness...
Petra Wahle, Graziella Di Cristo, Gudrun Schwerdtfeger, Maren Engelhardt, Nicoletta Berardi, Lamberto Maffei
Development (2003) 130 (3): 611–622.
Published: 1 February 2003
... vision. We now show that infusions of NT-4/5 and NGF (nerve growth factor) into visual cortex at the onset and the peak of the critical period accelerated LGN neuron growth. BDNF (brain-derived neurotrophic factor) was ineffective. The effects of neurotrophin on LGN development were clearly dissociated...
Paul R. Borghesani, Jean Michel Peyrin, Robyn Klein, Joshua Rubin, Alexandre R. Carter, Phillip M. Schwartz, Andrew Luster, Gabriel Corfas, Rosalind A. Segal
Development (2002) 129 (6): 1435–1442.
Published: 15 March 2002
... these zones. Here we show that migration of cerebellar granule cells out of their proliferative zone, the external granule cell layer (EGL), is impaired in Bdnf –/– mice. The reason for impaired migration is that BDNF directly and acutely stimulates granule cell migration. Purified Bdnf –/– granule cells show...
Includes: Multimedia, Supplementary data
Vincenzo Coppola, Jan Kucera, Mary Ellen Palko, Javier Martinez-De Velasco, W. Ernest Lyons, Bernd Fritzsch, Lino Tessarollo
Development (2001) 128 (21): 4315–4327.
Published: 1 November 2001
...-derived neurotrophic factor (BDNF), a TrkB ligand. As in NT3 and TrkC null mice, the proprioception system of these mutants failed to assemble. However, sensory fiber projections in the embryonic spinal cord suggest chemotropic effects of BDNF in vivo. In the dorsal root ganglia, the developmental dynamic...
Development (1999) 126 (19): 4365–4373.
Published: 1 October 1999
...Yasushi Enokido; Sean Wyatt; Alun M. Davies ABSTRACT Previous studies have shown that most neurons in cultures established during the early stages of neurogenesis in the embryonic mouse trigeminal ganglion are supported by BDNF whereas most neurons cultured from older ganglia survive with NGF...
José MarÍa Frade, Paola Bovolenta, Juan Ramón MartÍnez-Morales, Angeles Arribas, Julio A. Barbas, Alfredo RodrÍguez-Tébar
Development (1997) 124 (17): 3313–3320.
Published: 1 September 1997
... (NGF) acting via its p75 receptor (Frade, J. M., RodrÍguez-Tébar, A. and Barde, Y.-A. (1996) Nature 383, 166-168). Here, we show that the application of brain-derived neurotrophic factor (BDNF) to chick embryos in ovo prevented retinal cell death in the early period, whereas exogenously applied NGF...
Lynne M. Bianchi, Joanne C. Conover, Bernd Fritzsch, Thomas DeChiara, Ronald M. Lindsay, George D. Yancopoulos
Development (1996) 122 (6): 1965–1973.
Published: 1 June 1996
... study, we examined the developing vestibulo-cochlear system to determine the time course of neurotrophin dependence and to determine whether competition occurred among developing cochlear or vestibular neurons for available amounts of either brain-derived neurotrophic factor (BDNF) or neurotrophin-4/5...
Development (1995) 121 (5): 1301–1309.
Published: 1 May 1995
... preferences are due to a nontrophic effect of NGF. Unlike DRG cultured in NGF, those cultured in the presence of either NT-3 or BDNF often exhibited neurite growth preferences for the spinal cord cryosections; the effect was strongest in cultures containing NT-3. In addition, while a mixture of insulin...
Development (1994) 120 (6): 1573–1580.
Published: 1 June 1994
...Anna Buj-Bello; Luzia G. P. Pinon; Alun M. Davies ABSTRACT Recent work has shown that the survival of the nerve growth factor (NGF)-dependent trigeminal ganglion neurons of the mouse embryo is promoted by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) during the early stages...