..., which also leads to increased axon branching and decreased feeding ( Budnik et al., 1989 ; Neckameyer and Bhatt, 2012 ). Although defects are visible in the embryonic SNS, there appear to be two separate lethal phases. Some first instar larvae display feeding defects and die. This is particularly...

...Julian Ng Branching morphology is a hallmark feature of axons and dendrites and is essential for neuronal connectivity. To understand how this develops, I analyzed the stereotyped pattern of Drosophila mushroom body (MB) neurons, which have single axons branches that extend dorsally and medially. I...

...Daniel A. Gibson; Le Ma During nervous system development, axons generate branches to connect with multiple synaptic targets. As with axon growth and guidance, axon branching is tightly controlled in order to establish functional neural circuits, yet the mechanisms that regulate this important...

... appropriate target area. Thus, Eph/Ephrin signaling acts to guide a subset of mushroom body branches to their correct synaptic targets. * Author for correspondence (e-mail: jthomas@salk.edu ) 9 3 2006 © 2006. 2006 Drosophila Eph Axon branching Mushroom body...

... maturation of axonal arbors by directly influencing the stability of developing synapses. Here, we used in vivo time-lapse imaging to examine the relationship between synapse stabilization and axon branch stabilization, and to better understand the participation of BDNF in synaptogenesis. Green fluorescent...

...Jasmine D'Souza; Michael Hendricks; Sylvie Le Guyader; Sivan Subburaju; Barbara Grunewald; Klaus Scholich; Suresh Jesuthasan Visual system development is dependent on correct interpretation of cues that direct growth cone migration and axon branching. Mutations in the zebrafish esrom gene disrupt...

... for promotion of axonal branching of the sensory neurons. Colocalized expression of Robo, a receptor for Slit2, and PlexinA4 is observed not only in the primary sensory neurons of zebrafish embryos but also in the dendrites of the pyramidal neurons of the cortex of the mammals, and may be important...

... are divided into 118 classes. The development and differentiation of many neurons require the gene zag-1 , which encodes a δEF1/ZFH-1 Zn-finger-homeodomain protein. zag-1 mutations cause misexpression of neuron-specific genes, block formation of stereotypic axon branches, perturb neuronal migrations...

... medial or lateral to the TZ would encounter a gradient of increasingly favored attachment in the direction of the TZ. References Bastmeyer, M. and O'Leary, D. D. M. ( 1996 ). Dynamics of target recognition by interstitial axon branching along developing cortical axons. J. Neurosci. 16 , 1450...

... could be suppressed by expressing the UNC-119 protein after embryonic development; thus demonstrating that UNC-119 is required for the maintenance of the nervous system architecture. Finally, UNC-119 is located in neuron cell bodies and axons and acts cell-autonomously to inhibit axon branching...