... are an excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, remained...

...Daniel T. Grimes ABSTRACT Consistent asymmetries between the left and right sides of animal bodies are common. For example, the internal organs of vertebrates are left-right (L-R) asymmetric in a stereotyped fashion. Other structures, such as the skeleton and muscles, are largely symmetric...

...Masanori Abe; Reiko Kuroda ABSTRACT The establishment of left-right body asymmetry is a key biological process that is tightly regulated genetically. In the first application of CRISPR/Cas9 to a mollusc, we show decisively that the actin-related diaphanous gene Lsdia1 is the single maternal gene...

... to interpret different forms of tissue gradients to establish planar polarity. Planar polarity Planar cell polarity (PCP) Patterning Gradient Mathematical modelling Asymmetry Many animal tissues show coordinated polarisation of cells along a planar axis. Such planar polarisation results...

...Adam Davis; Nirav M. Amin; Caroline Johnson; Kristen Bagley; H. Troy Ghashghaei; Nanette Nascone-Yoder Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric...

... from intermingling with adjacent cells. Eph Ephrin Left-right Asymmetry DFCs Kupffer's vesicle Embryo Zebrafish In most vertebrate species, embryos initially develop symmetrically along the prospective body midline. Following gastrulation completion, a group of epithelial cells...

... summarize here, leaders in the field gathered at the symposium to discuss recent advances in understanding how left-right asymmetry is generated and utilized across the animal kingdom. * Authors for correspondence ( rburdine@princeton.edu ; tcaspar@emory.edu ) Competing interests The authors...

... the genetic pathways that specify neuronal asymmetries in the brain, little is known about genes that mediate the development of structural asymmetries between neurons on left and right. In this study, we identify daam1a as an asymmetric component of the signalling pathways leading to asymmetric morphogenesis...

.... We identified a mutation affecting zebrafish laminin β1a ( lamb1a ) that disrupts left-right asymmetry of the liver and pancreas. In these mutants, the liver spans the midline and the ventral pancreatic bud remains split into bilateral structures. We show that lamb1a regulates asymmetric left-right...

... to these proteins. These data support a model in which both early and later stages of fusion are highly asymmetric, and that this asymmetry extends beyond recognition and adhesion at the cell surface to cytoplasmic events associated with polymerization of actin. Mbc, which is present but not localized in founder...

...+ -sensitive target in left-right asymmetry and supports a model in which membrane targeted CaMK-II hetero-oligomers in nodal cells transduce the left-sided PKD2-dependent Ca 2+ signals to the LPM. CaMK-II (Camk2) Calcium Asymmetry Nodal Kupffer's vesicle Cilia Laterality disorders...

... financial interests. 16 2 2010 © 2010. 2010 FoxF FoxC let-381 Forkhead domain ceh-34 SIX2 homeodomain eya-1 Eyes absent Mesoderm Cell fate specification M lineage Coelomocyte Asymmetry C. elegans Proper animal development requires that each cell precisely...

... Biol. 13 , 357 -365. Essner, J. J., Amack, J. D., Nyholm, M. K., Harris, E. B. and Yost, H. J. ( 2005 ). Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 132 , 1247 -1260. Fliegauf, M...

...Myriam Roussigné; Isaac H. Bianco; Stephen W. Wilson; Patrick Blader The habenulae are evolutionarily conserved bilateral nuclei in the epithalamus that relay input from the forebrain to the ventral midbrain. In zebrafish, the habenulae display left-right (L/R) asymmetries in gene expression...

..., equivalent cells form two distinct populations composed of smaller inner cells and larger outer cells. These results reveal a unique feature of early mammalian development: an asymmetry may emerge autonomously in an equivalent population with no need for a priori intrinsic differences. Under...

... preferentially in AB. The polo-like kinase PLK-1, a positive regulator of mitotic entry, is distributed in an asymmetric manner in two-cell stage embryos, with more protein present in AB than in P 1 . We find that PLK-1 asymmetry is regulated by A-P polarity cues through preferential protein retention...

... ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive...

.... † Author for correspondence (e-mail: sanchez@neuro.utah.edu ) * Present address: London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK 25 8 2007 © 2007. 2007 Asymmetry BMP Planaria Regeneration Adult homeostasis...

... subsequent to this step to distinguish stem cell and terminal modes of neuron production. * Authors for correspondence (e-mail: jason@lifesci.dundee.ac.uk ; k.g.storey@dundee.ac.uk ) 13 3 2007 © 2007. 2007 FGF Asymmetry Live imaging Mitotic spindle Neurogenesis Spinal cord...

...., 2005 ; Kramer-Zucker et al., 2005 ). A number of calcium asymmetries surrounding Kupffer's vesicle have been reported( Sarmah et al., 2005 ; Webb and Miller, 2000 ). However, which calcium asymmetries may be relevant for the establishment of the left-right axis and how calcium asymmetries may...