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Keywords: Asymmetric division
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Journal Articles
Journal: Development
Development (2020) 147 (21): dev191411.
Published: 28 September 2020
.... Ankle2 Drosophila Asymmetric division Microcephaly Model of human disease Every in vivo approach used to study genetic variants associated with human disease has benefits and caveats. Whether the system is based on human cells in culture, primates, rodents, fish, flies, worms or yeast...
Journal Articles
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Neural development
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 6 April 2020
...Shilpa Kaur; Pauline Mélénec; Sabrina Murgan; Guillaume Bordet; Pierre Recouvreux; Pierre-François Lenne; Vincent Bertrand ABSTRACT Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt...
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (7): dev160747.
Published: 5 April 2018
... regulatory program. Lineage size Cell cycle Asymmetric division Combinatorial control Nervous system development Evolution of the CNS The central nervous system (CNS) is a defining feature of bilaterally symmetric animals (bilateria), and can be generally subdivided into the brain...
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Plant development
Journal: Development
Development (2017) 144 (3): 499–506.
Published: 1 February 2017
... diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it remains largely unknown. In plants, stomata, which are valves for gas exchange, are generated through several rounds of asymmetric divisions...
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (20): 3774–3784.
Published: 15 October 2016
.... and Huttner , W. B. ( 2005 ). The cell biology of neurogenesis . Nat. Rev. Mol. Cell Biol.   6 , 777 - 788 . 10.1038/nrm1739 Guo , M. , Jan , L. Y. and Jan , Y. N. ( 1996 ). Control of daughter cell fates during asymmetric division: interaction of Numb and Notch . Neuron   17...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1259–1270.
Published: 15 April 2016
... polarity components and extrinsic signals enforce proper tissue patterning. Asymmetric division bHLH proteins Epigenetic regulation of differentiation Lineage-specific stem cells Peptide signaling Stomata Summary: This Review summarises the transcription factor and epigenetic control...
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 1 May 2015
... re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors...
Journal Articles
Journal: Development
Development (2014) 141 (18): 3472–3482.
Published: 15 September 2014
... changed their division preference. i ArCoSs that are terminated or whose width is increased soon after the ‘injury ring’ indicate a change from asymmetric to symmetric divisions ( Fig. 7 I). i ArCoS that maintain their width before and after the ‘injury ring’ point to a fixed mode of asymmetric division...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2813–2824.
Published: 15 July 2014
...Shihadeh Anani; Shivani Bhat; Nobuko Honma-Yamanaka; Dayana Krawchuk; Yojiro Yamanaka In the mouse embryo, asymmetric divisions during the 8-16 cell division generate two cell types, polar and apolar cells, that are allocated to outer and inner positions, respectively. This outer/inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1842–1850.
Published: 15 May 2012
... the asymmetric division, showing the commitment of the future daughter cell to differentiation. The coordination of these two alternative cell cycles contributes to the continuous production of infective parasites, turning the tsetse fly into an efficient and long-lasting vector for African trypanosomes. We...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4375–4385.
Published: 15 October 2011
...Marjolein Wildwater; Nicholas Sander; Geert de Vreede; Sander van den Heuvel Tissue-specific stem cells combine proliferative and asymmetric divisions to balance self-renewal with differentiation. Tight regulation of the orientation and plane of cell division is crucial in this process. Here, we...
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Journal Articles
Journal: Development
Development (2011) 138 (14): 2903–2908.
Published: 15 July 2011
... 2011. 2011 F-actin Asymmetric division Meiosis Mouse Oocyte Asymmetric cell division requires correct spindle positioning with regards to the polarity axis of the mother cell ( Gonczy, 2008 ). In most models, mitotic spindle positioning depends on pulling forces produced by astral...
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Journal Articles
Journal: Development
Development (2011) 138 (5): 831–837.
Published: 1 March 2011
..., we report that CySCs divide asymmetrically through repositioning the mitotic spindle around anaphase. CySC spindle repositioning requires functional centrosomes, Dynein and the actin-membrane linker Moesin. Anaphase spindle repositioning is required to achieve high-fidelity asymmetric divisions...
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Journal Articles
Journal: Development
Development (2010) 137 (5): 715–724.
Published: 1 March 2010
... Center, Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Quebec H3A 1A3, Canada Competing interests statement 30 12 2009 © 2010. ICM Asymmetric division Primitive endoderm Epiblast Nanog Gata Mouse Primitive endoderm...
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Journal Articles
Journal: Development
Development (2009) 136 (20): 3393–3397.
Published: 15 October 2009
...Elena Rebollo; Mónica Roldán; Cayetano Gonzalez Spindle alignment along the apicobasal polarity axis is mandatory for proper self-renewing asymmetric division in Drosophila neuroblasts(NBs). In embryonic NBs, spindles have been reported to assemble orthogonally to the polarity axis and later...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2287–2296.
Published: 1 July 2009
...( Li et al., 2002 ). However, in a double mutant of B56 wdb ( wrd KG01108 wdb 12-1es ), we did not observe any defect in asymmetric division or self-renewal of neuroblasts (data not shown). Therefore Tws appears to be the B regulatory subunit of PP2A that controls the self-renewal of larval brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1801–1812.
Published: 1 June 2009
... surroundings. We report the sequence of cellular events, the dynamics of apically and basolaterally distributed macromolecules and the role of cell division during this archetypical EMT. EMT Asymmetric division Chicken Live cell imaging Neural crest Neural tube © 2009. 2009 23 3 2009...
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Journal Articles
Journal: Development
Development (2008) 135 (18): 3001–3005.
Published: 15 September 2008
... indicate that the vast majority, if not all, of GFP-labeled p2 progenitors divide once to produce V2a/V2b neuron pairs,indicating that V2a and V2b neurons are generated by the asymmetric division of pair-producing progenitor cells. Together with evidence that Notch signaling is involved in the cell fate...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3781–3787.
Published: 1 November 2007
.../cyclosome (APC/C) during this process. Attenuation of APC/C activity disrupts the asymmetric localisation of the adapter protein Miranda and its associated cargo proteins Staufen, Prospero and Brat, but not other components of the asymmetric division machinery. We demonstrate that Miranda is ubiquitylated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2183–2193.
Published: 1 June 2007
... syndrome. We show that these mutations disrupt spindle formation, resulting in frequent polyploid cells in larval brains. In addition, dlkb1 mutations affect asymmetric division of larval neuroblasts (NBs); they suppress unequal cytokinesis, abrogate proper localization of Bazooka, Par-6, DaPKC and Miranda...