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Keywords: Amnion
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Journal Articles
Journal: Development
Development (2022) 149 (20): dev200263.
Published: 20 September 2022
... embryogenesis. These complex tasks are resolved through an intricate combination of signals controlling the induction of extraembryonic lineages and, at the same time, safeguarding the pluripotent epiblast. Here, we delineate the signals orchestrating primate epiblast and amnion identity. We encapsulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev150433.
Published: 23 July 2018
... these studies, which suggest that the posterior epiblast and/or the nascent amnion in pregastrulation human embryos is a likely source of hPGCs, and that a different gene regulatory network controls PGCs in humans compared with in the mouse. Such studies on the origins and mechanisms of hPGC specification...
Journal Articles
Journal: Development
Development (2018) 145 (13): dev157222.
Published: 2 July 2018
... from a simple bilayer into a multilayered embryo enveloped by its extra-embryonic membranes. Impaired development of the amnion, the innermost membrane, causes major malformations. To clarify the origin of the mouse amnion, we used single-cell labelling and clonal analysis. We identified four clone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 175–186.
Published: 15 January 2017
... that determine amnion differentiation will be required to specify this extraembryonic lineage efficiently from naïve primate ESCs in vitro . Moreover, this experiment demands a detailed knowledge of the molecular signature of amniotic epithelial cells in vivo for meaningful endpoint analysis. Future studies...
Journal Articles
Journal: Development
Development (2012) 139 (18): 3343–3354.
Published: 15 September 2012
... primitive streak-like structure in mutant amnion accompanied by ectopic Nodal expression. This suggests that BMP/Smad5 signaling contributes to negative regulation of Nodal . In cultured cells, we find that BMP-activated Smad5 antagonizes Nodal signaling by interfering with the Nodal-Smad2/4-Foxh1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2415–2424.
Published: 1 July 2007
... , an expanded domain forms two distinct extra-embryonic tissues, the amnion and serosa. The analysis of approximately 20 different dorsal-ventral patterning genes suggests that the initial specification of the mesoderm and ventral neurogenic ectoderm is highly conserved in flies and mosquitoes. By contrast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (17): 3399–3409.
Published: 1 September 2006
... of the allantois and for amnion closure, as demonstrated by loss of Bmp signalling. By contrast, the appearance of ectopic PGC-like cells and regionalized ectopic vasculogenesis and haematopoiesis in thickened Smad5 m1/m1 amnion are amnion defects that have not been associated with loss of Bmp signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3955–3966.
Published: 15 August 2004
... of the ventral pteryla, midventral apterium and amnion. The embryonic proximal somatopleural mesoderm is determined to form a feather-forming dermis at 2 days of incubation (E2), while the embryonic distal and the extra-embryonic somatopleure remain open to determination. We found a progressive, lateral...