... and lipid studies reveal that the lipid droplet-associated Adipose Triglyceride Lipase provides the substrate for prostaglandin production during Drosophila follicle development, ultimately regulating actin remodeling and promoting fertility. Actin cytoskeleton Lipid droplets Prostaglandin...

... polarity and epidermal morphogenesis. Actin cytoskeleton Adherens junctions Epidermis Morphogenesis Planar cell polarity Proper polarization of cells and cellular structures along the plane of a tissue, or planar cell polarity (PCP), is essential for embryonic development and tissue...

... branched actin assembly is indispensable for melanoblasts populating the skin of the developing mouse embryo. Arp2/3 Melanoblasts Migration Actin cytoskeleton Skin pigmentation Tissue morphogenesis is in balance with cell migration. During development, cell movements are tightly regulated...

.../Rac GTPases in nascent myotubes and effects changes in the actin cytoskeleton. FGF signals are thus essential regulators of myotube guidance that act through cytoskeletal regulatory proteins to pattern the musculoskeletal system. * Present address: Kite Pharma, El Segundo, CA 90245, USA...

...) have a dynamic actin cytoskeleton that drives their expansion to a diameter of 10 μm. Although multiple proteins have been identified as components of RCs, we lack a basic understanding of how RC proteins interact together to form and regulate the RC cytoskeleton. Thus, here, we optimized a procedure...

... mutagenesis of HtsRC revealed its requirement in the recruitment of the ring canal F-actin cytoskeleton. We present genetic evidence consistent with HtsRC being the CRL3 Kelch substrate, as well as biochemical evidence indicating that HtsRC is ubiquitylated and degraded by the proteasome. Finally, we identify...

... free barbed F-actin ends, which might initiate the branching activity of the Arp2/3 complex ( Svitkina and Borisy, 1999 ; Pantaloni et al., 2000 ; Volkmann et al., 2001 ; Amann and Pollard, 2001 ; Ichetovkin et al., 2002 ). Ongoing reorganization of the actin cytoskeleton in S3A neurons might...

... © 2014. Published by The Company of Biologists Ltd 2014 Convergence and extension Non-canonical Wnt signaling Zebrafish Mutated in colorectal cancer (Mcc) Actin cytoskeleton Mutated in colorectal cancer ( MCC ) was first identified in 1991 as a candidate tumor suppressor gene...

..., and on the other hand identify singed as a new target of Breathless signal, establishing a link between guidance cues, the actin cytoskeleton and tracheal morphogenesis. An f riboprobe was generated using the following primers: forward, 5′-AGATACAGATCGCCCAGCAG-3′; reverse, 5′-TGTGATTTGCCAGACATGGT-3...

... membrane-enriched lipid essential for actin cytoskeleton remodeling in many cellular events, including phagocytosis ( Botelho et al., 2004 ). We constructed a reporter for PtdIns(4,5) P 2 by tagging the pleckstrin homology (PH) domain of human phospholipase C δ1, a high-affinity PtdIns(4,5) P 2 -binding...

... signaling pathway Actin cytoskeleton Drosophila discs epithelia The conserved Hippo (Hpo) signal transduction pathway has emerged as a crucial regulator of tissue size in both Drosophila and mammals ( Edgar, 2006 ). In Drosophila , the Hpo pathway comprises a kinase cascade in which the Hpo...

... organization. Genes Dev. 8 , 2986 -2995. Lantz, V. A., Clemens, S. E. and Miller, K. G. ( 1999 ). The actin cytoskeleton is required for maintenance of posterior pole plasm components in the Drosophila embryo. Mech. Dev. 85 , 111 -122. Lehmann, R. and Nusslein-Volhard, C. ( 1986 ). Abdominal...

... μm in B-D. DT,tracheal dorsal trunk; SC, spiracular chamber. To visualise the Actin cytoskeleton during the invagination process, we expressed GFP-Actin in the spiracle invaginating cells and followed in vivo cell shape changes. GFP-Actin preferentially accumulated at the apical side...

.... * Author for correspondence (e-mail: loc@nhlbi.nih.gov ) 20 7 2006 © 2006. 2006 Connexin 43 Neural crest cell Focal contact Actin cytoskeleton Cell motility Neural crest cells are ectomesenchymal cells derived by epithelialmesenchyme cell transformation from the dorsal...

...Tamás Matusek; Alexandre Djiane; Ferenc Jankovics; Damian Brunner; Marek Mlodzik; József Mihály Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described...

... tubules demonstrates that its activity is required to regulate the reorganisation of the actin cytoskeleton during the process of convergent extension. In addition, overexpression of cv-c in the developing tubules gives rise to actin-associated membrane extensions. Thus, Cv-c function is required...

...: regulators of the actin cytoskeleton and cell migration. Annu. Rev. Cell Dev. Biol. 19 , 541 -564. Kwiatkowski, A. V., Gertler, F. B. and Loureiro, J. J. ( 2003 ). Function and regulation of Ena/VASP proteins. Trends Cell Biol. 13 , 386 -392. Lanier, L. M. and Gertler, F. B. ( 2000 ). From Abl...

... and embryos lacking maternal and zygotic Pten function display phenotypes consistent with a function for PTEN in the organization of the actin cytoskeleton. In freshly laid eggs, the germ plasm determinants oskar mRNA and Vasa are not localized properly to the posterior cytocortex and pole cells do not form...

... effects are most likely due to an expanding number of LPA-mediated morphogenetic events during later stages. Fig. 9. Zygotic expression of LPA receptors is necessary to maintain the density of the actin cytoskeleton at the late blastula stage and for normal Xenopus development. (A) Depletion...

... and found it to be a large and complicated gene that encodes a pair of large conserved proteins of unknown biochemical function. ‡Author for correspondence (e-mail: pna@virginia.edu ) 5 5 2001 © 2001. 2001 furry Morphogenesis Actin cytoskeleton Drosophila The adult...