...-autonomously. One current model is that factors released from presynaptic axons organize postsynaptic differentiation directly beneath the nerve terminal. Here, we used neuromuscular junctions (NMJs) of the zebrafish primary motor system to test this model. Clusters of neurotransmitter(acetylcholine) receptors...

..., is sufficient to activate the multiple pathways leading to presynaptic and postsynaptic differentiation in vivo. In addition,we find that Musk protein can be clustered at synaptic sites, even if Musk mRNA is expressed uniformly in muscle. Moreover, acetylcholine receptor clustering and motor terminal branching...

... the gene encoding the adult acetylcholine receptor (AChR) ε subunit, which replaces its fetal counterpart, the γ subunit, at the skeletal neuromuscular junction during early postnatal life. Several aspects of postnatal maturation, including synapse elimination, proceeded normally in the absence...

...Jicheng Tang; Sangmee Ahn Jo; Steven J. Burden ABSTRACT Signaling between nerve and muscle is mediated by multiple mechanisms, including two transcriptional pathways. Signals provided by the nerve terminal activate transcription of acetylcholine receptor (AChR) genes in myofiber nuclei near...

...H. R. Brenner; A. Herczeg; C. R. Slater ABSTRACT To test the hypothesis that synaptic basal lamina can induce synapse-specific expression of acetylcholine receptor (AChR) genes, we examined the levels mRNA for the and -subunits of the AChR in regenerating rat soleus muscles up to 17 days...

...Sangmee Ahn Jo; Steven J. Burden ABSTRACT Nuclei in the synaptic region of multinucleated skeletal myofibers are transcriptionally distinct, since acetylcholine receptor genes are transcribed at a high rate by these nuclei, but not by nuclei elsewhere in the myofiber. Although this spatially...

...Joshua R. Sanes; Yvette R. Johnson; Paul T. Kotzbauer; Jacqueline Mudd; Theresa Hanley; Jean-Claude Marttnou; John P. Merlie ABSTRACT Acetylcholine receptors (AChRs) are highly concentrated in the postsynaptic membrane at the neuromuscular junction. To investigate mechanisms that lead...

... may act to reduce motoneuron death by providing increased access to muscle-derived neurotrophic molecules. 20 06 1989 © 1989 by Company of Biologists 1989 cell death motoneuron acetylcholine receptor chick embryo spinal cord synaptogenesis skeletal muscle neuromuscular...