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Keywords: AGM region
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Journal Articles
Journal: Development
Development (2023) 150 (23): dev201972.
Published: 6 December 2023
...) region is a tightly regulated process. Previously, we conducted spatial transcriptomic analysis of the human AGM region at the end of this period (CS16/CS17) and identified secreted factors involved in HSC development. Here, we extend our analysis to investigate the progression of dorso-ventral polarised...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200025.
Published: 11 February 2022
... cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver . Development 129 , 4891 - 4899 . 10.1242/dev.129.21.4891 Lefkopoulos , S. , Polyzou , A. , Derecka , M. , Bergo , V...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1284–1289.
Published: 15 April 2016
... provided that the original work is properly attributed. Summary: A quantitative approach reveals how the pre-HSC pool undergoes dramatic growth in the AGM region and, by E11.5, reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver. AGM region HSC Embryo Pre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3319–3323.
Published: 1 September 2014
... and can give rise to all blood cell lineages. The AGM region is an important intra-embryonic site of HSC development and a wealth of evidence indicates that HSCs emerge from the endothelium of the embryonic dorsal aorta and extra-embryonic large arteries. This, however, is a stepwise process that occurs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1017–1031.
Published: 15 March 2011
... key issues currently circulating in this field. * Author for correspondence ( a.medvinsky@ed.ac.uk ) Competing interests statement The authors declare no competing financial interests. © 2011. 2011 AGM region Yolk sac Placenta dHSC Pre-dHSC The ontogeny...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4179–4191.
Published: 15 September 2005
...Samir Taoudi; Aline M. Morrison; Hirofumi Inoue; Ruby Gribi; Janice Ure; Alexander Medvinsky The yolk sac and the para-aortic splanchnopleura/aorta-genital ridges-mesonephros (P-Sp/AGM) region are the main sites of haematopoietic activity in the mouse embryo at the pre-liver stage of development...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (21): 4891–4899.
Published: 1 November 2002
...Parasakthy Kumaravelu; Lilian Hook; Aline M. Morrison; Jan Ure; Suling Zhao; Sergei Zuyev; John Ansell; Alexander Medvinsky In the developing mouse embryo the first definitive(transplantable-into-the-adult) haematopoietic stem cells/long-term repopulating units (HSC/RUs) emerge in the AGM region...
Includes: Multimedia, Supplementary data