Issues
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Cover image
Cover Image
Cover: Ventral view of a Drosophila embryo during the morphogenetic process of head involution reveals a complex network of actomyosin cables that help insulate morphogenetic movements from one another. Labelling is for the cable revealing F-actin via Phalloidin (red), cell junctions via E-Cadherin (blue) and the actomyosin cable component Zasp52 tagged with GFP (green). See Research article by Ashour et al. (dev201238).
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RESEARCH HIGHLIGHTS
EDITORIAL
DEVELOPMENTAL TWISTS
INTERVIEWS
HYPOTHESIS
The evolution of gastrulation morphologies
Summary: This Hypothesis reviews the mechanisms that underlie the plasticity of vertebrate gastrulation during evolution and under experimental manipulation, and discusses the effects of the increase in yolk volume on the morphology of gastrulation.
STEM CELLS AND REGENERATION
MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control
Summary: The protein MERISTEM-DEFECTIVE regulates Arabidopsis meristem function through its role as a splicing factor, mediated through splicing targets RSZ33, ACC1 and SR34.
A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone
Summary: Genetic analysis of a network of 11 Notch-dependent and -independent her genes reveals redundant activities to provide robust maintenance of neural stem cells in the zebrafish thalamic proliferation zone.
RESEARCH ARTICLES
Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds
Highlighted Article: Assessment of cardiomyocyte number and ploidy dynamics in two mouse strains, C57BL/6J and A/J, reveals involvement of Tnni3k and Runx1 in divergent developmental paths to differing final ploidy composition in myocardium.
Temporally and regionally distinct morphogenetic processes govern zebrafish caudal fin blood vessel network expansion
Summary: Longitudinal analysis of the development of the zebrafish tail fin vasculature illustrates how blood vessels assemble in a stepwise manner to irrigate a mature organ.
Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling
Summary: First transcriptomic analysis of the forming vestibular lamina reveals a role for Hedgehog signalling in coordinating development of the teeth and oral vestibule.
An ancient testis-specific IQ motif-containing H gene regulates specific transcript isoform expression during spermatogenesis
Summary: Iqch mutant mice reveal that Iqch controls a network of alternative splicing events in postmitotic germ cells that are necessary to establish the correct protein isoforms required for spermatid development.
TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans
Summary: The short isoform of TOM-1/tomosyn inhibits growth cone protrusion downstream of the netrin receptor UNC-5 during growth cone outgrowth, whereas long isoforms have a pro-protrusive role.
Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks
Summary: Zasp52 is a key component of supracellular actomyosin cables during epithelial morphogenesis that serve to insulate morphogenetic changes from each other.
TECHNIQUES AND RESOURCES
An end-to-end pipeline based on open source deep learning tools for reliable analysis of complex 3D images of ovaries
Summary: An accessible image analysis method for biologists that includes easy-to-use deep learning algorithms and is designed for accurate quantitative measurement of ovarian content from complex 3D fluorescent images.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.