Cover: The surface of zebrafish retinal glia cells, called Müller glia, colour-coded by depth. Data were derived by processing Tg(Tp1:VenusPEST) transgenic reporter confocal images with the GliaMorph toolkit, a biomedical image analysis system that facilitates automatic extraction of 3D quantitative features of glia. See Research article by Kugler et al. (dev201008).
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Embracing the diversity of model systems to deconstruct the basis of regeneration and tissue repair
Summary: This Meeting Review provides an overview of the exciting topics discussed during the eighth EMBO conference in the series ‘The Molecular and Cellular Basis of Regeneration and Tissue Repair’ held in September 2022.
The role of Evi/Wntless in exporting Wnt proteins
Summary: This Review summarises mechanisms of Wnt ligand export and recent structural insights, with a focus on the Wnt transport protein Evi/Wntless.
Successful therapeutic intervention in new mouse models of frizzled 2-associated congenital malformations
Highlighted Article: Autosomal dominant Robinow syndrome is successfully modeled in mice for the first time and a therapeutic intervention strategy established for potential translation to human patients.
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
Highlighted Article: The bHLH transcription factor HAND2 regulates key gene regulatory networks within the developing endocardium and its DNA occupancy within regulated genes is predictive of transcriptional enhancers.
Contribution of vasculature to stem integrity in Arabidopsis thaliana
Summary: Inflorescence stem mechanical integrity relies on coordinated cell growth in inner tissues and physical support provided by vascular bundles.
CNKSR2, a downstream mediator of retinoic acid signaling, modulates the Ras/Raf/MEK pathway to regulate patterning and invagination of the chick forebrain roof plate
Summary: CNKSR2 is a previously unreported downstream mediator of RA signaling that modulates the Ras/Raf/MEK pathway for inducing roof plate marker expression during midline invagination of the chick forebrain roof plate.
hnRNPH1 establishes Sertoli–germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice
Highlighted Article: A crucial role is revealed for hnRNPH1 in SCs during spermatogenesis and a potential molecular regulatory network invoving hnRNPH1 in establishing Sertoli–germ cell crosstalk.
Exploring generic principles of compartmentalization in a developmental in vitro model
Summary: Cell-like arrays in self-organizing egg extracts feature a dynamically coarse-graining geometry similar to two-dimensional foams without long-range order. Similar results from embryos and tissues suggest common principles of space compartmentalization.
Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development
Summary: Unbiased phenotyping of the mouse hypothalamus using single-cell RNA sequencing reveals the crucial role of early postnatal thyroid hormone receptor α1 signaling for hypothalamic oligodendrocyte maturation.
TECHNIQUES AND RESOURCES
Cre recombinase microinjection for single-cell tracing and localised gene targeting
Highlighted Article: TAT-Cre microinjection can be used to trace cell lineages and edit genes at custom anatomical locations in postimplantation mouse embryos, allowing prospective clonal analysis and genetic mosaic studies in progenitor cell populations.
GliaMorph: a modular image analysis toolkit to quantify Müller glial cell morphology
Summary: GliaMorph allows for multi-dimensional Muller glial cell analysis, enabling image-level as well as subcellular morphological assessments that are robust, adaptable and easy to use.
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Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Development presents… Outstanding Paper Prize Finalists
On Wednesday 19 April, Development hosted a webinar celebrating the finalists for Development’s Inaugural Outstanding Paper Prize. The talks and Q&As were hosted by our Deputy Editor, Steve Wilson (UCL).
Development Journal Meeting 2023
The Abstract deadline for our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ is 23 June 2023. Find out more and apply here
Keeping up with the Node
Thirteen years on from its launch, the Node continues to be a place to share research stories, opinions, job adverts and event listings. Development have published a recent Editorial reviewing some of our most popular features, as well as introducing some new initiatives.