Summary: This Review draws on recent mechanistic studies across various species, tissues and injury contexts to explore the role that organs distant from an injury can play in regeneration.
An interactive resource of molecular signalling in the developing human haematopoietic stem cell niche
Summary: An in-depth and interactive exploration of molecular signalling in the human developmental haematopoietic stem cell niche at the spatial and single cell level.
Summary: RNF20 and UBE2B monoubiquitylate H2Bub and are associated with human congenital heart disease. Mutations affecting the H2Bub1-deposition complex result in abnormalities in mice and human iPSC-derived cardiomyocytes.
STEM CELLS AND REGENERATION
Summary: Gene overexpression experiments reveal that Wnt and BMP signaling have opposing roles in stickleback and zebrafish tooth replacement, playing positive and negative roles, respectively, on tooth regeneration rates.
Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas
Summary: Signals provided by reactive microglia and macrophages promote the formation of Muller glia-derived progenitors by activated HBEGF and FGF pathways.
Local auxin biosynthesis promotes shoot patterning and stem cell differentiation in Arabidopsis shoot apex
Summary: Locally produced auxin and transport control the patterning of the shoot apical meristem into the central zone, peripheral zone and rib meristem in Arabidopsis.
Embryonic organizer specification in the mud snail Ilyanassa obsoleta depends on intercellular signaling
Summary: Polar lobe inheritance, long thought to autonomously specify the 3D organizer cell in Ilyanassa, surprisingly acts by sensitizing the D lineage to an organizer-inducing signal from multiple overlying micromeres.
Highlighted Article: Using an EIF4ENIF1-deficient mouse model to mimic premature ovarian insufficiency reveals that the deficiency of this RNA-binding protein was related to oocyte mitochondria hyper-fusion.
Two modes of gene regulation by TFL1 mediate its dual function in flowering time and shoot determinacy of Arabidopsis
Highlighted Article: TFL1, a transcriptional cofactor, regulates floral transition and shoot indeterminacy. This study quantifies the dynamic localisation of TFL1 and characterises its role in gene expression at these stages of reproductive development.
ABA guides stomatal proliferation and patterning through the EPF-SPCH signaling pathway in Arabidopsis thaliana
Summary: ABA mediates repression of stomatal proliferation through the EPF2-SPCH pathway and controls stomatal spacing in parallel with EPF1 in Arabidopsis.
Highlighted Article: Sharp transitions between successive cell states (‘jumps’) occur during developmental progression. This study shows that jumps can be induced by the emergence of collective signalling in the cell population.
Highlighted Article: The plant hormones auxin and abscisic acid coordinately regulate hypocotyl elongation, a key stage of seedling establishment.
Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function
Summary: An RNA element in the furina 3′ untranslated region recognises the RNA-binding protein Ybx1 and functions in translational control of FurinA in zebrafish embryos.
Summary: Zld-assisted binding of both activators and repressors is crucial for patterning at multiple levels of the Drosophila segmentation hierarchy.