Summary: This Review discusses the chromatin modifications associated with the mammalian female inactive X chromosome and their relevance to gene silencing and potential for therapeutic modulation.
Summary: NOTCH3 signalling has a crucial role in early development of the human placenta by promoting expansion of its founder cell: the epithelial trophoblast stem cell.
Summary: Activation of platelet-derived growth factor signaling in sclerotome microenviroment facilitates zebrafish primitive erythropoiesis.
Molecular compartmentalization in a syncytium: restricted mobility of proteins within the sea urchin skeletogenic mesenchyme
Highlighted Article: Transcription factors and effector proteins have limited mobility within the skeletogenic syncytium of the sea urchin embryo.
Cell-type-specific interacting proteins collaborate to regulate the timing of Cyclin B protein expression in male meiotic prophase
Summary: Timing of expression of conserved cell cycle regulator Cyclin B is controlled by multiple cell-type-specific proteins in Drosophila meiotic prophase male germ cells.
FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor
Summary: Two formin proteins, FRL and DAAM, are required for the sealing of the interommatidial cell lattice necessary for optical insulation of the photoreception units in the insect compound eye.
Summary: Through genetic deletion, we disrupt netrin 1 signaling in the developing kidney and uncover previously unreported roles in mediating vascular patterning and maturity and proper kidney development.
Summary: Netrin 1 secreted by cortical stromal progenitors in the kidney regulates vascular patterning of the renal arterial tree, as well as vascular smooth muscle cell differentiation via Klf4.
Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata
Summary: The morphological speciality of axons emerging from dendrites has been shown to be important during development: basket cell axons emerging from dendrites grow more rapidly and form denser terminal fields.
Dysregulation of the endoplasmic reticulum blocks recruitment of centrosome-associated proteins resulting in mitotic failure
Summary: In Drosophila, centrosomal maturation and endoplasmic reticulum condensation occur with similar timings at mitotic onset, and endoplasmic reticulum dysregulation leads to spindle weakening and failures of mitosis.
Summary: Formulation of a mathematical model to investigate the interplay between morphogen gradients and tissue mechanics in regulating the collective cell movements that drive hindgut morphogenesis in the chick embryo.
Highlighted Article: A mathematical model for growing networks by oscillations on nodes reproduces germline cyst topologies in invertebrates and reveals the nonintuitive effects of model parameters including cell-cell coupling on network structure.
The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility
Summary: The microtubule-severing enzymes KATNA1 and KATNAL1 function collectively to regulate multiple aspects of microtubule dynamics during spermatogenesis.
Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development
Highlighted Article: Hypoglycosylated FSH21 improves the establishment of cell-to-cell communication during early folliculogenesis in mouse, which promotes increased follicular growth and enhanced oocyte quality.
Genome-wide identification of notochord enhancers comprising the regulatory landscape of the brachyury locus in mouse
Summary: Multi-omics assays of purified embryonic and in vitro-generated cells identify thousands of notochord enhancers including TNE2, which is essential for notochord function and tail development of the mouse embryo.
Summary: The early Arabidopsis embryo is surrounded by a proteinaceous envelope that is distinct from the cuticle and embryo sheath.
TECHNIQUES AND RESOURCES
Summary: Saliency analyses show that a deep convolutional network trained to accurately classify chick embryos from images bases this classification on biologically relevant features.