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Special Issue: Metabolic and Nutritional Control of Development and Regeneration



Summary: This Spotlight gives an overview of the role of nutritional and metabolic cues during development, across different species and multiple levels of complexity. 


Summary: This Review highlights recent mechanistic insights into how common diets and specific nutrients impact developmental processes and cell fate decisions in healthy and disease contexts.


Summary: An auxin-regulated class VIII myosin, ATM1, is required for root cell proliferation in response to sugar.

Summary: The fish-specific translation initiation factor Eif4e1c, which is absent in terrestrial species, regulates growth and heart regeneration in zebrafish.

Summary: Shmt, a key player in one-carbon metabolism, is essential for optic lobe development, and its loss leads to neuroepithelia apoptosis and morphological defects with consequent loss of neuroblasts and neurons.

Summary: Measuring the amino acid requirements of germline stem cells reveals that spermatogonia require glutamine for protection against reactive oxygen species.


Summary: Using mouse genetics and human neural organoids, we assessed the consequences of reducing the activity of a metabolic enzyme, DHFR, on the production of different neuronal subtypes during neocortex development.

Summary: Heme-deficient primitive RBCs induced HSPC ferroptosis through the disruption of iron trafficking, and the iron-ROS-lipid peroxidation axis is responsible for defective HSPC production.

Summary: Genetic and lipid studies reveal that the lipid droplet-associated Adipose Triglyceride Lipase provides the substrate for prostaglandin production during Drosophila follicle development, ultimately regulating actin remodeling and promoting fertility.

Summary: Transgenic, micromorphological, dynamic and multi-omic analyses in wheat reveal the underlying mechanism of the Green Revolution gene Rht-B1b in modulation of plant architecture and yield component traits.

Summary: Supplementation of the intermediate metabolite SAM in the methionine metabolic pathway alleviates damaged intestinal epithelium and inflammatory infiltration caused by IEC-specific deletion of Mat2a and partly ameliorates the DSS-induced colitis.

Summary: In Drosophila embryos, Jabba is essential for correct sorting of glycogen granules and lipid droplets into different tissues by preventing inappropriate interactions between these organelles.

Summary: Gestational iron deficiency leads to altered neuronal progenitor cell proliferation in the embryo and is associated with changes in specific interneuron subtypes in the offspring.

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