Summary: This Review describes the tissue-resident gastric stem cell population that drives stomach patterning and lineage specification during development and continued homeostatic maintenance and regeneration in adulthood.
STEM CELLS AND REGENERATION
aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for planarian head regeneration
Summary: alx-3 plays an essential role in integrating wound signals, priming neurogenesis and successful head regeneration.
Summary: Perturbation of glia with ets-1(RNAi) alters neuronal gene expression, impedes animal movement and impairs nervous system architecture in planarians.
Highlighted Article: The mechanisms of Wnt signaling in butterfly wings, identifying Frizzled2 as a receptor for WntA that mediates major effects on color pattern induction.
Summary: The kinesin-1 heavy chain promotes the localization and motility of the NEKL-3 kinase in axons. This process is required for axon targeting and its disruption may cause neurodevelopmental disorders.
Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis
Summary: The first molecular description of pupal Drosophila blood cells provides insights into blood cell functional diversification and plasticity during metamorphosis, a phase marked by programmed cell death and inflammatory signals.
Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling
Summary: The role of wnt9a/b in assembly of myocardial progenitor cells at the embryonic midline to form the heart cone and then initiate leftward-directed heart tube elongation.
Highlighted Article: Transcriptomic and epigenomic analyses of Drosophila mutants reveals that, in the absence of Pc, the eye is reprogrammed into a wing through inappropriate formation of the Vestigial–Scalloped complex.
Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice
Highlighted Article: Loss of balanced retinoic acid signaling from the meninges causes cortical folding due to regionalized changes to neurogenesis that affect the tangential distribution of neurons and cortical expansion.
An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish
Summary: Longitudinal live imaging of zebrafish skin development revealed an active traveling wave coupled to cellular processes as a mechanism for producing periodic patterning of skin appendages.
Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme
Summary: The first report indicating that tongue mesenchyme is required for taste papilla cell differentiation.
Summary: The neuronal furin-like proprotein convertase KPC-1 in Caenorhabditis elegans requires catalytic activity to non-autonomously regulate the Menorin adhesion complex from adjacent tissues, thereby providing negative feedback during dendrite development.
An acytokinetic cell division creates PIP2-enriched membrane asymmetries leading to slit diaphragm assembly in Drosophila nephrocytes
Summary: An acytokinetic cell division breaks the initial membrane symmetry in embryonic garland nephrocytes creating PIP2-enriched membrane microdomains suitable for slit diaphragm assembly.
Highlighted Article: Loss of Rasa1 in zebrafish leads to cavernous arteriovenous malformations with venous-specific increased MEK/ERK activity and cell size, and disrupted angiogenesis and blood flow.
The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila
Summary: Examination of the migration and morphogenesis of Drosophila visceral muscle precursors reveals how these multinucleated precursors form the stereotypic arrangement of longitudinal gut muscles and identifies Tey as a crucial regulator of this process.
Summary: Dynamic expression of Zbtb16 underlies downregulation of early segmental fgf3 expression in the zebrafish hindbrain, enabling the correct pattern of Fgf signalling at later stages when Fgf20 organizes neurogenesis.
TECHNIQUES AND RESOURCES
Summary: A chicken model, termed gSAMURAI, has been developed that can be used as the surrogate for PGC-mediated gene editing, producing a high-grade germline chimera by inducible ablation of host germ cells.