STEM CELLS AND REGENERATION
Summary: The Erk and Akt signaling pathways have both common and distinct roles in the control of size, shape and patterned gene expression in an organoid model of mammalian gastrulation.
Summary: Somatic niche cells in the worm gonad relay basement membrane signals to the primordial germ cells using integrin receptors in order to control stem cell quiescence.
Summary: Neurogenesis redirects β-catenin from the adherens junctions to the nucleus to stimulate genes that control the growth and guidance of commissural axons in developing chick spinal cord.
kcnj13 regulates pigment cell shapes in zebrafish and has diverged by cis-regulatory evolution between Danio species
Summary: The potassium channel gene kcnj13 regulates the shapes of all pigment cells in zebrafish stripes and its cis-regulatory evolution contributes to pattern diversification in Danio fish.
Highlighted Article: In both fly and human development, chamber-specific asymmetry in cardiomyocyte ploidy (DNA content) is conserved and reducing ploidy in flies leads to impaired cardiac function, mimicking human cardiomyopathies.
SWI/SNF complexes are required for retinal pigmented epithelium differentiation and for the inhibition of cell proliferation and neural differentiation programs
Summary: Spatial transcriptomic of embryonic control and SWI/SNF-deficient RPE uncovers RPE-specific gene regulatory networks and their dependence on the SWI/SNF complexes, which further inhibit the neural and cell proliferation genes.
Summary: The role of mechanical force in regulating gene expression at the tendon-bone interface and the consequences for the structure of the tendon matrix.
Summary: Nolz1 and its homologs are part of the evolutionarily conserved transcriptional regulator toolkits that are essential for the development of respiratory organs.
Summary: Development of the hepatic artery is controlled by Slit/Robo signalling, and perturbed morphogenesis of this artery impacts liver regeneration.
A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression
Summary: Identification of an endocytic recycling pathway that permits the rapid re-utilization of membrane for the formation of pseudocleavage furrows in the early Drosophila embryo.
TECHNIQUES AND RESOURCES
Summary: This resource of single cell gene expression profiles during embryonic fly heart development expands research opportunities and translation to other species when using Drosophila to study heart development and disease.