Cover: Confocal image of a horizontal section through a wild-type adult Drosophila eye, stained for Retinol dehydrogenase B (RdhB, green), N-cadherin (red) and Rhodopsin 1 (Rh1, blue). The image shows the curved external surfaces of the corneal lenses and their attachments to the secondary and tertiary pigment cells stained for RdhB, as well as the rhabdomeres stained for Rh1 that extend through the full depth of the retina. See Research article by Wang et al. (dev200217).
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The mechanical forces that shape our senses
Summary: This Review gives an overview of our current understanding of how physical forces influence developing sensory organs, both in the embryo and in organoid cultures.
STEM CELLS AND REGENERATION
Notch-dependent DNA cis-regulatory elements and their dose-dependent control of C. elegans stem cell self-renewal
Highlighted Article: Notch-dependent DNA cis-regulatory elements work together in their developmental context in C. elegans to shape a transcriptional gradient, control stem cell pool size, and govern differentiation onset.
Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish
Summary: Jag2b-driven Notch signaling regulates efna1b expression in the somite to modulate the Wnt16–Dlc/Dld signaling axis, which is required for hematopoietic stem cell specification.
Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development
Summary: Conserved roles for Pdgfrb signalling in development and regeneration suggest a limited capacity of mural cells to self-renew or contribute to other cell types during tissue regeneration.
RhoA/ROCK signaling antagonizes bovine trophoblast stem cell self-renewal and regulates preimplantation embryo size and differentiation
Highlighted Article: Signaling for self-renewal and differentiation revealed via systems biology analysis of the bovine blastocyst trophectoderm permits establishment of trophoblast stem cells and discovery of mechanisms surrounding placental development and differentiation.
Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis
Highlighted Article: src-1 acts in parallel or downstream of pathways involving Wnt and FGFRL factors to regulate positional information along the anteroposterior axis in planarian regeneration
Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development
Highlighted Article: Using a combination of live-cell imaging, single-cell sequencing and genetic manipulation, the molecular connections are defined between cell cycle checkpoints, mitotic divisions and aneuploidy in mammalian preimplantation embryos.
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos
Summary: Premeiotic endoreplication is a mechanism of production of unreduced eggs in parthenogenetic gecko complexes. The endoreplication might be induced by a failure of oocytes with the original ploidy during pachytene in the obligate parthenogenetic hybrids.
FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis
Summary: Foxp4 has a phase-dependent role in beige adipocyte differentiation, priming their early cell fate commitment but attenuating their thermogenic activation at mature stages.
A 3D molecular map of the cavefish neural plate illuminates eye-field organization and its borders in vertebrates
Summary: At the end of gastrulation, the vertebrate eye field is already highly regionalized, and species-specific or morphotype-specific pattern variations are apparent.
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac
Summary: A previously unreported role for FOXO1 as a key transcriptional repressor regulating both pre-flow arterial specification and subsequent vessel remodeling within the murine yolk sac.
The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye
Summary: Terminal differentiation of the Drosophila eye requires Blimp-1, a transcription factor induced by ecdysone signaling, that promotes photoreceptor rhabdomere extension and increases corneal lens refractive power.
Traip controls mushroom body size by suppressing mitotic defects
Summary: Analysis of the effect on brain development of mutations in the Drosophila traip gene reveals that Traip suppresses DNA bridges and premature neural stem cell loss to ensure proper brain size.
SCARECROW is deployed in distinct contexts during rice and maize leaf development
Summary: The transcription factor SCARECROW patterns stomata in rice leaves, whereas in maize it predominantly patterns the inner leaf.
TECHNIQUES AND RESOURCES
Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species
Summary: A protocol to establish mammary organoids from non-traditional model species, providing a physiologically relevant 3D in vitro model for comparative studies centered on mammary gland development and cancer.
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Development presents… Outstanding Paper Prize Finalists
On Wednesday 19 April, Development hosted a webinar celebrating the finalists for Development’s Inaugural Outstanding Paper Prize. The talks and Q&As were hosted by our Deputy Editor, Steve Wilson (UCL).
Development Journal Meeting 2023
The Abstract deadline for our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ is 23 June 2023. Find out more and apply here
Keeping up with the Node
Thirteen years on from its launch, the Node continues to be a place to share research stories, opinions, job adverts and event listings. Development have published a recent Editorial reviewing some of our most popular features, as well as introducing some new initiatives.