Issues

Summary: This Review highlights the recent discoveries that govern gynoecium and fruit development in Arabidopsis and presents the currently known gene regulatory networks from gynoecium initiation until fruit maturation.

Highlighted Article: Transgenic overactivation of Notch signaling, which is required for bone regeneration following segmental mandibulectomy in zebrafish, accelerates bone healing through more efficient conversion of the cartilage callus to bone.

Highlighted Article: Knockout of newt Hox13 genes reveals that Hox13 function is conserved between limb development and regeneration, but that Hoxa13 has a predominant role in digit formation, unlike in mice.

Summary: The activity of fatty acid binding proteins and fatty acid synthase are required for the formation of Müller glia-derived progenitors in the retina.

Summary: Single cell transcriptomics and genetic studies reveal unique properties of Olig2-expressing neural stem cells in the adult subventricular zone and their developmental trajectory.

Summary: Two subtypes of astrocyte progenitor cells, marked by SPARC and SPARCL1, are distributed in discrete regions of the mouse forebrain at the start of gliogenesis.

Highlighted Article: This paper describes a pathway in which high temperatures are perceived by the leaves to promote an auxin-dependent signal that accelerates vascular regeneration, graft formation and plant parasitism in distant tissues.

Summary: Cortical gradient expression of the area patterning gene Nr2f1 spatially and temporally controls corticopontine topographic connectivity in layer V projection neurons.

Highlighted Article: The gene regulatory network that controls segmentation in the wasp Nasonia is functionally similar to that of Drosophila, despite different modes of segmentation and 300 million years of divergence.

Summary: KIFC1 is important for microtubule acetylation-based spindle stability, and also plays a role in actin dynamics and spindle migration through Fmn2 and ARP2/3 function during mouse oocyte meiosis.

Summary: Warm and cold temperatures reduce Drosophila egg production through distinct ovarian effects, providing insight into how the current climate crisis affects insect reproduction.

Summary: Polycomb repressor complex 2 inactivation results in selective effects on mouse hypothalamic development, increasing glutamatergic/GABA cells, while reducing dopamine, Hcrt and Tac2-Pax6 cells.

Summary: The H3.3 chaperone Hira complex has a maternal effect function in oocyte developmental competence and embryogenesis by modulating chromatin condensation and transcriptional quiescence.

Summary: The stereotyped assembly of the zebrafish pectoral fin vasculature is documented from first migratory sprout into the limb bud, to the adult-like form of the 4-week-old larva.