Issues

Summary: This Spotlight discusses how the Turing model, first published 70 years ago, has been implemented and adapted to understand developmental principles.

Summary: This Review examines the mechanisms and functions of regulated DNA methylation and demethylation, highlighting how these dynamics contribute to mammalian development and tissue maturation.

Highlighted Article: Tankyrase inhibition suppresses trophectoderm induction to stabilise human naïve pluripotent stem cells. This effect is mediated by stabilising angiomotin to restrict YAP activity.

Highlighted Article: A combination of high-resolution immunofluorescence, electrophysiology and Fos immunohistochemistry uncovers a postnatal period of selective synaptic refinement of glutamate and GABA inputs to raphe 5-HT neurons.

Summary: OsFLZ2 interacts with OsMADS51 and inhibits the transcriptional activation activity of OsMADS51 in modulating the expression of its target gene Early heading date 1, thus delaying flowering in rice.

Highlighted Article: The UBE4B-KLHL22 E3 cascade tightly controls activation of mTOR signaling and sustains perinatal neurogenesis at an appropriate level during mouse brain development.

Highlighted Article: Zebrafish Nanog regulates oogenesis and early embryogenesis through translational control of maternal mRNA via a mechanism whereby Nanog acts as a transcriptional repressor to suppress transcription of eef1a1l2.

Summary: Cell surface-localized arabinogalactan proteins control the expression strength of transcription factors to regulate cell wall-modifying enzymes, thereby fine-tuning the timing of gametophore initiation in moss.

Summary: This study provides a mechanistic link between eye patterning and the establishment of functionally distinct retinal regions, and reveals that the temporal retina preferentially controls specific aspects of visual function.

Summary: blf and drl cluster genes act as determinants in the fate commitment of progenitor cells during primitive hematopoiesis by constraining the expression of vasculogenesis-promoting and monocytopoiesis-promoting genes.

Summary: A highly conserved C-terminal cysteine in EXC-4/CLIC and the Gα-Rho/Rac pathway regulate outgrowth of the C. elegans excretory canal cell, linking a metazoan-specific motif in CLICs to the emerging function of these proteins in Rho/Rac signaling.