Issues
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Cover image
Cover Image
Cover: A Drosophila melanogaster egg chamber at stage 10. Using CRISPR/Cas9 genome editing, the Tbx20 homolog Midline (MID) was endogenously tagged with sfGFP (green). MID sets the posterior boundary of the dorsal appendages' primordia, here marked by the transcription factor Broad (red). See Research report by Stevens et al. (dev201016).
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RESEARCH HIGHLIGHTS
DEVELOPMENTAL TWISTS
PERSPECTIVES
SPOTLIGHT
Age reprogramming: cell rejuvenation by partial reprogramming
Summary: This Spotlight evaluates models of age reprogramming in light of recent studies that have provided molecular insights into the concept of age reprogramming.
HYPOTHESIS
Transposon control as a checkpoint for tissue regeneration
Summary: This Hypothesis argues that the process of tissue regeneration is conducive to transposable element activities that, if left uncontrolled, create an insurmountable barrier to tissue repair.
REVIEW
Cranium growth, patterning and homeostasis
Summary: We review the roles of osteoprogenitor cells, suture-derived stem cells and signaling pathways that control skull development and homeostasis in normal development and disease states.
STEM CELLS AND REGENERATION
A method for stabilising the XX karyotype in female mESC cultures
Summary: Exploiting the X-linked reporters of the Xmas mESC system to improve female mESC culture facilitates the study of karyotypically correct cells and thus female pluripotency.
Chimeric 3D gastruloids – a versatile tool for studies of mammalian peri-gastrulation development
Highlighted Article: This study demonstrates the feasibility of chimeric gastruloids for the analyses of cell-intrinsic and cell non-autonomous gene functions, exemplified for the Tbx factors Eomes and brachyury.
RESEARCH REPORTS
Shared cis-regulatory modules control expression of the tandem paralogs midline and H15 in the follicular epithelium
Summary: CRISPR/Cas9 genome editing reveals a coordinating-cis-regulatory module that regulates tandem paralog genes during posterior fate determination in female Drosophila ovaries.
Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons
Summary: Evidence for a previously unreported role for a cell-adhesion receptor in regulating neuronal migration in mice by suppressing attraction for a secreted protein.
RESEARCH ARTICLES
The microtubule end-binding proteins EB1 and Patronin modulate the spatiotemporal dynamics of myosin and pattern pulsed apical constriction
Summary: Microtubule network reorganization, mediated by moving Patronin platforms and EB1-dependent microtubule growth, tunes cell and tissue contractility by modulating actomyosin dynamics through the spatiotemporal regulation of RhoGTPase activity.
Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation
Highlighted Article: Computational modelling reveals the likely complementary roles of auxin and auxin signalling in one of the earliest steps in the formation of plant lateral roots, prebranch site formation.
The ERM-1 membrane-binding domain directs erm-1 mRNA localization to the plasma membrane in the C. elegans embryo
Summary: In C. elegans, erm-1 mRNA localization to plasma membranes requires the ERM-1 membrane-binding domain.
Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Summary: ‘Illuminati’ is a type of functional instability, caused by epigenetic mechanisms, that occurs most frequently in larval neuroblasts and is enhanced in a neuroblast-derived tumor in Drosophila.
Microtubule-associated ROP interactors affect microtubule dynamics and modulate cell wall patterning and root hair growth
Summary: The ROP interactors ICR2 and ICR5 are microtubule-associated proteins that have unique and redundant functions in secondary wall patterning in the xylem and root hair polar growth.
ID1 and CEBPA coordinate epidermal progenitor cell differentiation
Summary: ID1 is a key coordinator of epidermal development, acting to balance progenitor proliferation with differentiation. A functional crosstalk between CEBPA and Id1 orchestrates epidermal lineage progression.
Regulators specifying cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues
Summary: Ectodermal, mesodermal and endodermal tissues in ascidian embryos control the cell cycle through Cdkn1 and Myc, which are under control of transcription factors that specify cell fate.
The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes
Summary: Mahjong, an E3 ligase substrate receptor, functions in cell competition through its E3 ligase activity and is independent of its binding partner and apicobasal polarity regulator lethal giant larvae (Lgl).
Hybridization alters maternal and paternal genome contributions to early plant embryogenesis
Summary: Parent-of-origin transcriptomes from hybrid Arabidopsis zygotes are more complex than previously reported and do not accurately reflect maternal effects seen in early isogenic embryos.
Drosophila GSK3β promotes microtubule disassembly and dendrite pruning in sensory neurons
Summary: RNAi reveals that fly GSK3β kinase acts synergistically with Par-1 kinase to promote dendrite pruning via microtubule disassembly during Drosophila metamorphosis.
Anther development in Arabidopsis thaliana involves symplastic isolation and apoplastic gating of the tapetum-middle layer interface
Summary: Apoplastic movement between the tapetum and middle layer of the developing Arabidopsis anther is gated by a previously uncharacterised apoplastic barrier, the peritapetal strip.
Separable mechanisms drive local and global polarity establishment in the Caenorhabditis elegans intestinal epithelium
Highlighted Article: Live-imaging and intestine-specific protein depletion in Caenorhabditis elegans reveal that apico-basolateral polarity establishment can be temporally and genetically separated locally, across individual cells, and globally, across a tissue.
Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development
Summary:Wnt5a-overexpressing mice reveal for the first time that that Wnt5a can function as an orienting cue to polarize mouse skin.
TECHNIQUES AND RESOURCES
Single-cell RNA-sequencing analysis of early sea star development
Highlighted Article: Single-cell RNA-sequencing analysis of early sea star development contrasts the results of primordial germ cell specification in the sea urchin, and enables deeper comparative studies in tractable developmental models.
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro
Summary: Here, we report robust and reliable tools to model mammalian meiotic initiation in vitro and isolate pure populations of millions of cells undergoing the mitosis-to-meiosis transition for biochemical assays.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.