Issues

Summary: This Hypothesis article describes how global DNA methylation serves as the basis of a master plan for managing the accessibility of genome regulatory elements controlling gene expression profiles during development.

Summary: VEGFC plays a role in maintaining hematopoietic stem cell fate decisions within the hemogenic endothelium, a finding which may have the potential to improve pluripotent stem cell differentiation protocols.

Summary: Embryonic expression of Pthlha precedes Ihha in establishing the negative-feedback loop that regulates endochondral growth zone formation and establishment of this pattern depends on the force of muscle contraction.

Summary: This study identifies a previously unreported mechanical signaling pathway through Yap and retinoic acid that regulates lung branching morphogenesis.

Summary: Astrocyte-intrinsic and -extrinsic activities of the Fat1 cadherin influence astrocyte migration polarity, proliferation and maturation. Their disruption impacts retinal vascular development and maintenance.

Summary: The Foxn3 transcription factor and microRNA miR-216b can modulate formation of amacrine cells in the developing mouse retina, suggesting a new regulatory pathway for retinal interneuron formation.

Summary: C2CD6 contains a calcium-dependent membrane targeting C2 domain and is associated with and regulates the localization and organization of the CatSper calcium channel complex in mouse sperm flagella.