Summary: This Hypothesis article describes how global DNA methylation serves as the basis of a master plan for managing the accessibility of genome regulatory elements controlling gene expression profiles during development.
STEM CELLS AND REGENERATION
Summary: VEGFC plays a role in maintaining hematopoietic stem cell fate decisions within the hemogenic endothelium, a finding which may have the potential to improve pluripotent stem cell differentiation protocols.
Pthlha and mechanical force control early patterning of growth zones in the zebrafish craniofacial skeleton
Summary: Embryonic expression of Pthlha precedes Ihha in establishing the negative-feedback loop that regulates endochondral growth zone formation and establishment of this pattern depends on the force of muscle contraction.
Summary: This study identifies a previously unreported mechanical signaling pathway through Yap and retinoic acid that regulates lung branching morphogenesis.
Astrocyte-intrinsic and -extrinsic Fat1 activities regulate astrocyte development and angiogenesis in the retina
Summary: Astrocyte-intrinsic and -extrinsic activities of the Fat1 cadherin influence astrocyte migration polarity, proliferation and maturation. Their disruption impacts retinal vascular development and maintenance.
Summary: The Foxn3 transcription factor and microRNA miR-216b can modulate formation of amacrine cells in the developing mouse retina, suggesting a new regulatory pathway for retinal interneuron formation.
Summary: C2CD6 contains a calcium-dependent membrane targeting C2 domain and is associated with and regulates the localization and organization of the CatSper calcium channel complex in mouse sperm flagella.