Issues

Summary: This Review gives an overview of cerebellum development and morphogenesis, which is orchestrated by the coordinated action of cells from various lineages, some of which exhibit plasticity upon injury.

Highlighted Article: Coupled expansion of cardiac endothelial cells and cardiomyocytes within a myovascular niche regulates cardiac growth and regeneration in neonatal mice and likely humans.

Highlighted Article: Hemocyte ablation in Drosophila melanogaster with a novel strong hemocyte-specific driver causes pupal lethality under germ-free conditions.

Summary: Genetic, biochemical and imaging experiments demonstrate a role for SGRP-1 in stabilization of adherens junctions by binding to the HMP-1 M domain during C. elegans embryonic morphogenesis.

Highlighted Article: RTL5 and RTL6 are eutherian-specific genes acquired from a retrovirus in microglia in the brain. They play important roles in pathogen clearance in the eutherian brain immune system.

Summary:STIP plays a key role during ovule development in Arabidopsis thaliana by controlling integument formation and female germline progression.

Summary: This study establishes a transcriptional atlas of the cell fate decisions underlying LPM specification, subdivision and development of the chicken forelimbs.

Summary: Hippo signaling kinases LATS1 and LATS2 phosphorylate downstream effectors YAP/TAZ to regulate the TGFB-induced epithelial-to-mesenchymal transition in the migratory neural crest on the dorsal cranial neural tube.

Summary: Yolk sac-derived macrophages of zebrafish deficient in the transcriptional regulator Trim33 (Tif1γ) have a much reduced lifespan.

Summary: The ARID2 and BRG1 components of the PBAF chromatin remodeling complex fulfill essential but distinct functions during gametogenesis.

Highlighted Article: Histone turnover-mediated reduction of H3K27me3 during spermiogenesis is important for chromatin accessibility in early mouse embryos.

Highlighted Article: Profiling of proteome dynamics using nanoproteomics uncovers the relationship between RNAs and proteins during Arabidopsis thaliana early embryogenesis.

Summary: A new technique combining Easi-CRISPR with in utero electroporation allows efficient and rapid visualization of endogenous proteins in embryonic brain tissue.

Summary: A new automated phenotyping method for stigma and ovary development in wheat highlights the potential for genetic variation that could benefit hybrid breeding.