Issues
-
Cover image
Cover Image
Cover: A Drosophila syncytial embryo at NC 13 telophase, with centrioles (magenta), microtubules (green) and DNA (blue) highlighted. See Research article by Fang and Lerit (dev200426).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
PERSPECTIVE
INTERVIEWS
SPOTLIGHT
Symbiosis of disciplines: how can developmental biologists join conservationists in sustaining and restoring earth's biodiversity?
Summary: Environmental biologists need data from developmental biology; developmental biology should be considered when discussing multiple issues regarding environmental degradation and global climate change, and during our current climate of significant environmental upheaval.
REVIEW
Symbiosis: the other cells in development
Summary: This Review addresses how microbial symbioses impact animal development from gametogenesis through adulthood, and assesses which developmental processes may or may not be influenced by microbial symbioses.
HUMAN DEVELOPMENT
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells
Highlighted Article: A continuous pseudotime trajectory of human trophoblast development from zygote to mid-gestation determines the in vivo counterpart of in vitro trophoblast cultures and identifies key regulators of human trophoblast stem cell self renewal.
A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas
Summary: Analysis of a new resource for the PDX1 cistrome and single-cell transcriptome of the developing pancreas suggests that PDX1 maintains adult β-cell plasticity to allow adaptation and dedifferentiation under pathological conditions.
STEM CELLS AND REGENERATION
Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure
Highlighted Article: By generating a single-cell transcriptomic atlas of early cardiac development, we uncover transcriptional mechanisms governing lineage relationships between heart field progenitors and their progeny.
RESEARCH REPORTS
Brain vascular damage-induced lymphatic ingrowth is directed by Cxcl12b/Cxcr4a
Highlighted Article: Following brain vascular injury, Cxcl12b/Cxcr4a become active to control the direction of lymphangiogenesis and cerebrovascular regeneration, thus avoiding uncontrolled vessel growth.
Absence of a robust mitotic timer mechanism in early preimplantation mouse embryos leads to chromosome instability
Highlighted Article: Prolongation of M phase in early mouse embryos does not arrest the cell cycle, and embryos continue to develop but show cohesion fatigue and micronuclei, which can lead to chromosomal instability.
RESEARCH ARTICLES
Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis
Summary: Genetic and imaging approaches identify ethylene-regulated reactive oxygen species-producing enzymes that drive root hair initiation in Arabidopsis.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
Summary: Coupling of FAK with TRIM25/USP9x controls ERG degradation in endothelial cells, thus determining vascular patterning in the retina.
PILS proteins provide a homeostatic feedback on auxin signaling output
Highlighted Article: Auxin exerts a posttranslational feedback regulation on the PILS proteins, contributing to cellular auxin homeostasis and providing robustness to plant growth and development.
Foxl2 is required for the initiation of the female pathway in a temperature-dependent sex determination system in Trachemys scripta
Summary: The forkhead transcription factor FOXL2 is a key upstream regulator of temperature-dependent female sex determination in the red-eared slider turtle Trachemys scripta.
The pseudobranch of jawed vertebrates is a mandibular arch-derived gill
Highlighted Article: The skate pseudobranch is a gill serial homologue and reveals the ancestral gill arch-like nature of the jawed vertebrate mandibular arch.
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation
Summary: A versatile light-sheet imaging setup enabling simultaneous live imaging of multiple mouse embryos for 48 h, an approach that offers insight into the onset of oscillatory signaling dynamics and the segmentation clock.
Female meiosis II and pronuclear fusion require the microtubule transport factor Bicaudal D
Summary: BicD is required for normal female meiosis and pronuclear fusion, processes that are needed to form the first zygotic nucleus to start a new life.
Pinch2 regulates myelination in the mouse central nervous system
Summary: Analysis of conditional knockout mice reveals Pinch2 as a key regulator of CNS myelin formation and maturation, preventing excessive myelination and ensuring myelin stability via its interactions with RhoA and Cdc42.
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents
Summary: Single cell RNA sequencing in the vomeronasal organ reveals a crucial role for Dll4-Notch1 signaling in the formation of V1R+/apical and V2R+/basal vomeronasal sensory neurons of rodents.
Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure
Summary: Detailed characterization of the contribution of distinct morphogenetic processes and mechanical tissue coupling during neural tube closure, a process indispensable for central nervous system formation in vertebrates.
Casein kinase 1α regulates murine spermatogenesis via p53-Sox3 signaling
Summary: A previously unreported mechanism to explain the role of CK1α in the regulation of spermatogenesis.
A Diaphanous and Enabled-dependent asymmetric actin cable array repositions nuclei during Drosophila oogenesis
Summary: An asymmetric actin cable array generated by the differential localization of Diaphanous and Enabled is necessary to reposition nurse cell nuclei and complete oogenesis in Drosophila.
Orb-dependent polyadenylation contributes to PLP expression and centrosome scaffold assembly
Summary: The Drosophila CPEB ortholog Orb regulates the centrosome component PLP by promoting post-transcriptional polyadenylation, thereby ensuring proper centrosome function, mitotic fidelity and genome stability.
CORRECTION
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.