Issues
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Cover image
Cover Image
Cover: E16 mouse lung showing expression of Hopx (white, alveolar type I cell marker), Sftpc (green, alveolar type II cell marker) and Tgfbi (red, myofibroblast marker) by RNA in situ hybridization (blue, DAPI marking nuclei). During the canalicular stage of lung development, Sftpc+ early alveolar type II cells demonstrate distinctly spatial separation from Hopx+ early alveolar type I cells and adjacent Tgfbi+ myofibroblasts, suggesting early fate commitment of the epithelium. See Research article by Negretti et al. (dev199512)
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RESEARCH HIGHLIGHTS
PERSPECTIVE
INTERVIEWS
SPOTLIGHT
The zebrafish issue: 25 years on
Summary: In this Spotlight, five zebrafish researchers reflect on how the 1996 zebrafish issue of Development has influenced their career and their community.
REVIEW
Sculpting with stem cells: how models of embryo development take shape
Summary:In vitro engineering of embryo-like structures (stembryos) from pluripotent stem cells offers unique possibilities to understand how boundary conditions that impose geometrical, mechanical and biochemical constraints pattern and shape the mammalian embryo.
STEM CELLS AND REGENERATION
Flower meristem maintenance by TILLERS ABSENT 1 is essential for ovule development in rice
Summary:TAB1 is identified as a central factor that promotes ovule development in rice by regulating stem cell maintenance at a later stage of flower development.
RESEARCH REPORTS
A stop or go switch: glycogen synthase kinase 3β phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules
Summary: GSK3β-mediated phosphorylation of kinesin 1 heavy chain is essential for kinesin 1 motility, cargo/membrane attachment and ATPase activity, but not for microtubule binding.
DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development
Highlighted Article: Although DPPA2 and DPPA4 are essential for activating two-cell embryo-specific transcripts in mouse embryonic stem cells, they are dispensable for mouse zygotic genome activation and pre-implantation development.
RESEARCH ARTICLES
Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus
Summary: The mangrove killifish, a self-fertilizing vertebrate model, allows rapid identification of the mutated genes noto and msgn1 from mutant strains and their genetic roles in tail bud development.
Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis
Summary: This study demonstrates at the molecular level how maternally provided SMC3 supports the first round of DNA replication and chromosome segregation in the zygote to enable successful embryogenesis.
A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis
Highlighted Article: Through theory and computational modeling, cell-cell communication is revealed to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis.
Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival
Highlighted Article: Conditional knockout mouse models reveal maternal stores of Dppa2 and Dppa4 are dispensable for zygotic genome activation, contrasting findings in embryonic stem cells. However, both maternal and zygotic Dppa2/4 are required for development.
Generation and timing of graded responses to morphogen gradients
Summary: Morphogen gradients are known to subdivide a naive cell field into distinct zones of gene expression, but morphogens can also induce a graded response within such domains.
Translation-dependent mRNA localization to Caenorhabditis elegans adherens junctions
Highlighted Article: An smFISH-based survey identifies a subset of mRNAs encoding junctional components that localize at or in proximity to the adherens junction through a translation-dependent mechanism.
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis
Summary: The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis and acts together with DMRT6 and STRA8 as a module in the meiotic initiation regulatory network.
KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development
Summary: Analysis of a graded series of KATNB1 loss-of-function models reveals that katanin proteins are required to regulate the vast majority of microtubule-based processes in male germ cell development.
Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis
Summary: Frazzled is required in the Drosophila female germline for the progression of egg chambers through mid-oogenesis, regulating germline survival by inhibiting apoptosis.
TECHNIQUES AND RESOURCES
Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants
Highlighted Article: Intermediate progenitor cells are a distinct population of multipotent cells that contribute to all three differentiated blood cell types in Drosophila and act as signaling centers to neighboring cells.
A single-cell atlas of mouse lung development
Summary: Time-series single-cell transcriptomic analysis identifies previously unrecognized transitional states, population dynamics, fate trajectories and gene-expression evolution in the developing mouse lung.
CORRECTION
Correction: The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis
Pathway to Independence programme

We’re excited to announce our new Pathway to Independence programme, aimed at supporting postdocs as they go on the job market. Find out more about the scheme in our Editorial.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration

We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Transitions in development: Daniel Grimes

Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.