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Issues

RESEARCH HIGHLIGHTS

PERSPECTIVE

INTERVIEWS

SPOTLIGHT

Summary: In this Spotlight, five zebrafish researchers reflect on how the 1996 zebrafish issue of Development has influenced their career and their community.

REVIEW

Summary:In vitro engineering of embryo-like structures (stembryos) from pluripotent stem cells offers unique possibilities to understand how boundary conditions that impose geometrical, mechanical and biochemical constraints pattern and shape the mammalian embryo.

STEM CELLS AND REGENERATION

Summary:TAB1 is identified as a central factor that promotes ovule development in rice by regulating stem cell maintenance at a later stage of flower development.

RESEARCH REPORTS

Summary: GSK3β-mediated phosphorylation of kinesin 1 heavy chain is essential for kinesin 1 motility, cargo/membrane attachment and ATPase activity, but not for microtubule binding.

Highlighted Article: Although DPPA2 and DPPA4 are essential for activating two-cell embryo-specific transcripts in mouse embryonic stem cells, they are dispensable for mouse zygotic genome activation and pre-implantation development.

RESEARCH ARTICLES

Summary: The mangrove killifish, a self-fertilizing vertebrate model, allows rapid identification of the mutated genes noto and msgn1 from mutant strains and their genetic roles in tail bud development.

Summary: This study demonstrates at the molecular level how maternally provided SMC3 supports the first round of DNA replication and chromosome segregation in the zygote to enable successful embryogenesis.

Highlighted Article: Through theory and computational modeling, cell-cell communication is revealed to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis.

Highlighted Article: Conditional knockout mouse models reveal maternal stores of Dppa2 and Dppa4 are dispensable for zygotic genome activation, contrasting findings in embryonic stem cells. However, both maternal and zygotic Dppa2/4 are required for development.

Summary: Morphogen gradients are known to subdivide a naive cell field into distinct zones of gene expression, but morphogens can also induce a graded response within such domains.

Summary: An smFISH-based survey identifies a subset of mRNAs encoding junctional components that localize at or in proximity to the adherens junction through a translation-dependent mechanism.

Summary: The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis and acts together with DMRT6 and STRA8 as a module in the meiotic initiation regulatory network.

Summary: Analysis of a graded series of KATNB1 loss-of-function models reveals that katanin proteins are required to regulate the vast majority of microtubule-based processes in male germ cell development.

Summary: Frazzled is required in the Drosophila female germline for the progression of egg chambers through mid-oogenesis, regulating germline survival by inhibiting apoptosis.

TECHNIQUES AND RESOURCES

Highlighted Article: Intermediate progenitor cells are a distinct population of multipotent cells that contribute to all three differentiated blood cell types in Drosophila and act as signaling centers to neighboring cells.

Summary: Time-series single-cell transcriptomic analysis identifies previously unrecognized transitional states, population dynamics, fate trajectories and gene-expression evolution in the developing mouse lung.

CORRECTION

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