Issues
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Cover image
Cover Image
Cover: Dorsal view of a 4 day-old transgenic zebrafish larva expressing green (EGFPCAAX) and red (TagRFPCAAX) fluorescent proteins in nasal and temporal retinal ganglion cells in the eye, respectively. Corresponding nasal and temporal retinal axons project to distinct areas and form a map at the brain target (Z-projection, confocal imaging). See Research article by Spead et al. (dev199584)
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RESEARCH HIGHLIGHTS
PERSPECTIVE
OBITUARY
INTERVIEW
HYPOTHESIS
Cyclical fate restriction: a new view of neural crest cell fate specification
Summary: A novel hypothesis is presented incorporating a dynamic view of transcriptional states to explain how neural crest cells generate their diverse repertoire of cell types.
HUMAN DEVELOPMENT
KLF17 promotes human naïve pluripotency but is not required for its establishment
Summary: Given that KLF17 was shown to be sufficient, but not necessary, to establish naïve pluripotent hESCs, KLF17 might function as a peripheral regulator of human pluripotent stem cells.
STEM CELLS AND REGENERATION
Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation
Summary: This study reveals a new layer of regulation within the signaling network that controls differentiation of a Drosophila epithelial stem cell lineage.
RESEARCH ARTICLES
Calcium waves facilitate and coordinate the contraction of endfeet actin stress fibers in Drosophila interommatidial cells
Highlighted Article: Coordinated Ca2+ waves across the Drosophila eye facilitate actomyosin contractions at the basal endfeet of interommatidial cells, generating tensile forces that help to shape the convex curvature of the eye.
Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes
Summary: A genetic study revealing that endocytosis mediated by an atypical CUBAM endocytic receptor, composed of Amnionless and two Cubilin paralogues, regulates slit diaphragm remodelling in Drosophila nephrocytes.
Avian ceca are indispensable for hindgut enteric nervous system development
Highlighted Article: Dynamic WNT11 expression in the cecal region regulates enteric neural crest cell colonization of the colorectum, revealing an essential role of the ceca in avian enteric nervous system development.
An epigenetic circuit controls neurogenic programs during neocortex development
Summary: Epigenetic machinery centered on a LncRNA and the BAF complex temporally controls cell cycle progression and the neurogenic program of neocortical intermediate progenitors.
Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening
Summary: This study describes the first visualization of a topographic map forming and maturing in a living animal and identifies the adhesion molecule Contactin 2 as a key regulator in that process.
TECHNIQUES AND RESOURCES
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization
Summary: Signal amplification based on the mechanism of hybridization chain reaction enables multiplexed, quantitative, high-resolution imaging of protein and RNA targets in highly autofluorescent tissues.
In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor
Summary: Use of proximity biotin ligation to identify components of a Dynein localization complex and the development of a nanobody-based approach to identify the interactome of any GFP-tagged protein.
Single-cell reconstruction with spatial context of migrating neural crest cells and their microenvironments during vertebrate head and neck formation
Summary: A comprehensive map of the transcriptional landscape of the first four chick branchial arches that defines a spatio-temporal reference resource during patterning of the vertebrate head and neck.
Pathway to Independence programme

We’re excited to announce our new Pathway to Independence programme, aimed at supporting postdocs as they go on the job market. Find out more about the scheme in our Editorial.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration

We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Transitions in development: Daniel Grimes

Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.