Issues

Summary: This Review summarizes recent single-cell, genetic and transplantation studies demonstrating heterogeneity of satellite cells and fibroadipogenic progenitors in skeletal muscle regeneration.

Summary: Characterization of trophoblast organoids and trophoblast stem cells as exciting models of human placentation enables the selection of the most suitable system to address specific research questions.

Highlighted Article: The transcription factor NF-κB, together with downstream Wnt and Sox9, is required for Paneth and goblet cell fate decisions and for maintenance of the small intestinal stem cell niche.

Highlighted Article: Experiments in embryonic stem cells reveal how the coupling of cell fate decisions in a population leads to the self-organized differentiation of stable ratios of cell types.

Summary: This study demonstrates that, in mouse oocytes, AURKA is required for CPEB1-dependent translation, and it describes a new AURKB requirement to maintain translation levels through AURKA, a function crucial to generating euploid eggs.

Summary: This study demonstrates that Robo1/β-catenin/JAG1 signaling in basal epithelial cells regulates luminal Notch activity and alveolar progenitor differentiation, offering a non-hormonal way to target milk production and mitigate lactation insufficiency.

Summary: GAS1 acts as co-receptor that integrates signaling by sonic hedgehog and NOTCH in neural progenitor cells, which are essential for controlling the differentiation of the forebrain neuroepithelium.

Summary: Both increased and reduced BR signalling strength results in altered cell wall orientation in the Arabidopsis root, uncoupled from whole-root growth control.

Highlighted Article: Use of an ionophore to manipulate cytoplasmic zinc levels in nematode sperm reveals that zinc signaling is sufficient, but not always necessary, for sperm activation.

Highlighted Article: We used deep-learning tools to automate image analysis, including high-dimensional light-sheet images, of embryonic development and disease.

Summary: FAM71F1 interacts with RAB2A/B and regulates the formation of the acrosome in mice, the misregulation of which impacts male fertility.

Summary: In addition to their conserved roles in neuromuscular development of axial muscle in zebrafish, Agrin and Lrp4 also have secondary roles in constraining MuSK-dependent synapse formation in appendicular muscle.