Summary: This Spotlight article discusses the mechanisms that polyploid cardiomyocytes and their relationship with cardiac regeneration.
Summary: This Review emphasizes that the general principles of embryonic development and tissue homeostasis are similar, and that interactions between these disciplines will be beneficial for both research fields.
Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development
Summary: Using a temporospatially specific gain- and loss-of-function approach, this study reveals that Wnt/β-catenin signaling is crucial in early development of the mouse molar.
Highlighted Article: Epithelial tissues heterozygous for a ribosomal protein gene, which causes a variety of developmental abnormalities in humans, ensure robust morphogenesis by suppressing JNK-mediated apoptosis via Yorkie in Drosophila.
Summary: MPDZ patterns the apical membrane of auditory hair cells, and defects in hair bundle morphogenesis coincide with severe hearing loss in Mpdz mutants.
scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse
Summary: Single-cell RNA sequencing identifies interactions of TCF4 with non-bHLH transcription factors linked to neurodevelopmental and neuropsychiatric disease in the regulation of interhemispheric projection neuron development.
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway
Summary: Activation of the FOXO1-TP53INP1-p53-CDKN1A axis prevents G1/S progression in porcine ovarian somatic GCs during hypoxia.
Clathrin-mediated endocytosis is essential for the selective degradation of maternal membrane proteins and preimplantation development
Summary: This study reveals the significance of clathrin-mediated endocytosis in mammalian embryogenesis and the involvement of protein ubiquitylation in selective degradation of maternal membrane proteins during the oocyte-to-embryo transition.
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition
Highlighted Article: How spatial information and temporal maturation contribute to the production of discrete neuronal types from a continuum of progenitors in the developing pallium.
Summary: PDGFRα signaling regulates gene expression through alternative RNA splicing; ablation in the murine neural crest lineage of a downstream effector of PDGFRα signaling, the RNA-binding protein Srsf3, results in midline facial clefting.
Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2
Highlighted Article: Glypican 4 controls the planar polarity of endodermal cells during early segmentation in the zebrafish by regulating the distribution of Cadherin 2 through Rab5c-mediated endocytosis.
Arabidopsis vascular complexity and connectivity controls PIN-FORMED1 dynamics and lateral vein patterning during embryogenesis
Summary: VCC is a plasma membrane protein that controls the transition from pre-procambial into procambial cell fate during the formation of lateral vascular strands in Arabidopsis embryonic cotyledons.
Cell wall damage attenuates root hair patterning and tissue morphogenesis mediated by the receptor kinase STRUBBELIG
Highlighted Article: This study indicates that the mechanism through which the cell wall controls cell fate and morphogenesis in plants involves regulation of the receptor kinase STRUBBELIG.
The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses
Summary: The BMP antagonist Grem1 is expressed by committed deep-layer glutamatergic neurons in the embryonic mouse cortex. Grem1 conditional knockout mice display cortical and behavioral abnormalities.