Cover: Light-sheet imaging of Aurkbfl/fl;mTmG control E14.5 embryonic lung showing E-cadherin (yellow) expression throughout the lung epithelium, and Sox9 expression (blue) at the tip of the branches and in the tracheal cartilages. GFP is in pink. See Research article by Ah-Cann et al. (dev199543).
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Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies
Summary: This Review summarizes the current knowledge of mammalian tracheal development, which is distinct from lung in large part, and discusses the generation of tracheal tissues from human pluripotent stem cells.
Cell cycle control during early embryogenesis
Summary: This Review discusses emerging quantitative principles for how embryos coordinate cell cycle timing and morphogenesis.
Global proteomic analyses of human cytotrophoblast differentiation/invasion
Summary: The generation of a publicly available SWATH-MS global spectral library of human second-trimester primary villous cytotrophoblasts differentiating along an invasive pathway.
LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells
Summary: This study reveals the indispensable role of the lncRNA HBL1 in guiding PRC2 function during early human cardiogenesis, and uncovers the crosstalk of the cytosolic and nuclear regions of HBL1 to orchestrate human cardiac development.
Planar polarization of cilia in the zebrafish floor-plate involves Par3-mediated posterior localization of highly motile basal bodies
Summary: Floor-plate cilia planar polarization is crucial for cerebrospinal fluid directional flow in the zebrafish embryo nervous system. We describe the polarization dynamics involved and show that they depend on Par3 enrichment.
A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells
Summary: Genetic screening and in vivo conditional knockout studies show that Aurkb is required for early lung branching morphogenesis but not necessary for postnatal growth and repair of the adult lung after injury.
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations
Highlighted Article: MTHFR deficiency results in sperm DNA hypomethylation of regions enriched in potentially active young retrotransposons that are targets of a piRNA- and DNMT3C-dependent de novo DNA methylation pathway, leading to reproductive defects that are more severe in subsequent generations.
Gene expression variation in Arabidopsis embryos at single-nucleus resolution
Highlighted Article: A transcriptome atlas of Arabidopsis embryos constructed from single nuclei reveals cell-specific epigenetic and transcriptional regulatory features.
The molecular complex of ciliary and golgin protein is crucial for skull development
Summary: Synergistic molecular regulation of IFT20 and GMAP210 is required for intramembranous ossification, which has not been previously characterized in skull formation.
Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve
Highlighted Article: Compressive versus tensile stress regulates valve development through a molecular switch potentiating BMP-pSMAD1/5-driven growth and pSer-19-MLC2-driven contractility.
Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos
Summary: RNF114 exerts the effect of a ubiquitin E3 ligase in mouse oocytes under physiological conditions, mediating the degradation of substrates such as CBX5 and TAB1 for subsequent major zygotic genomic activation.
TECHNIQUES AND RESOURCES
Embryonic development in the acoel Hofstenia miamia
Summary: Comprehensive characterization of embryonic development in the acoel worm Hofstenia miamia with accompanying transcriptome data highlight its potential as a model species for insights into embryogenesis and stem cell biology.
Efficient generation of endogenous protein reporters for mouse development
Summary: We developed two complementary approaches in preimplantation mouse embryos, to enhance the efficiency of detecting endogenous proteins in vivo.
The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. For every Research Article and Review/Commentary article that is published in JEB (and our sister journals Development, Journal of Cell Science, Disease Models & Mechanisms and Biology Open), a native tree is planted in a forest in the UK.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Pathway to Independence Programme - introducing our first PI Fellows
In December 2022, we announced a new programme aimed at supporting researchers as they transition from postdoc to Principal Investigator. We are delighted to announce that we have now selected our first cohort of PI fellows, meet them here.
Development Journal Meeting 2023
We are delighted to announce that our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ will be held from 17-20 September 2023 at Wotton House, Surrey, UK. Find out more and register here.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.