Issues
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Cover image
Cover Image
Cover: Artistic rearrangement of leaf confocal micrographs displaying battery of fluorescently tagged cell fate determinants in response to injuries. Images created by Anju P. S., Dhanya Radhakrishnan and Abdul Kareem V. K. Artwork by Mabel Maria Mathew (Indian Institute of Science Education and Research, Thiruvananthapuram, India). See Research article by Radhakrishnan et al. (dev185710).
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RESEARCH HIGHLIGHTS
INTERVIEW
PRIMERS
Model systems for regeneration: Xenopus
Summary: This Primer gives an overview of Xenopus as a model system for studying regeneration, comparing the two species X. laevis and X. tropicalis, and highlighting how Xenopus studies have enhanced our understanding of the molecular mechanisms of regeneration.
SUMOylation in development and neurodegeneration
Summary: In this Primer, we review the roles of SUMO, a ubiquitin-like protein, in developmental processes such as signaling, epigenetic regulation, neurogenesis and neurodegeneration.
STEM CELLS AND REGENERATION
A coherent feed-forward loop drives vascular regeneration in damaged aerial organs of plants growing in a normal developmental context
Highlighted Article: The PLT-CUC2 module acts in a feed-forward loop to increase the local auxin biosynthesis at the wound site. This drives vascular regeneration in aerial organs of plants.
RESEARCH REPORTS
Epigenetic changes occur at decidualisation genes as a function of reproductive ageing in mice
Highlighted Article: Maternal age-induced epigenetic changes in the uterus interfere with the induction of decidualisation genes, and thereby impede the early gestational adaptations that are essential for a successful pregnancy.
Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry
Summary: Left-right asymmetric neurogenesis of the vertebrate habenula depends on tight control of Wnt/β-catenin signaling involving a Wif1-mediated regulatory feedback loop.
RESEARCH ARTICLES
Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development
Summary: Post-translational monoubiquitylation modification of key transcription factors plays a vital role in regulation of noradrenergic neuron development.
Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads
Summary: Differential occupation of two enhancers defines sex-specific regulation of Irx3 and Irx5 in fetal gonads: repressor marks inhibit in testes, while active marks engage with β-catenin/TCF to stimulate in ovaries.
Auxin fluxes through plasmodesmata modify root-tip auxin distribution
Highlighted Article: A multicellular model of auxin transport in the Arabidopsis root tip reveals the importance of intercellular plasmodesmata in maintaining auxin pattern and fluxes.
Spatiotemporal control of cell growth by CUC3 shapes leaf margins
Summary: The evolution of serrations at the leaf margin requires a fine tuning of cell growth; the transcription factor CUC3 is crucial for maintaining local and transient repression of growth in a few sinus cells.
CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice
Summary: Conditional knockout of Cxxc1 in mouse pre-meiotic germ cells led to a decrease in H3K4me3, dysregulation of crossover formation and meiotic arrest, revealing an essential role for CXXC1 in spermatogenesis and oogenesis.
Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development
Summary: The temporal transcription factor E93 controls both activation and deactivation of different target enhancers in the same cells to respond to spatial cues through regulation of chromatin accessibility.
Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons
Summary: Maintaining actin dynamics is crucial for cell motility. Post-transcriptional regulation plays a pivotal role in supporting actin dynamics during neuronal migration.
TECHNIQUES AND RESOURCES
Molecular and genetic regulation of pig pancreatic islet cell development
Highlighted Article: Transcriptional, signaling and cellular programs governing pig pancreatic islet development exhibit striking similarities to human islet ontogeny, providing a novel resource for advancing human islet replacement strategies.
A single cell transcriptome atlas of the developing zebrafish hindbrain
Summary: A single cell transcriptome at three stages of zebrafish hindbrain development provides a valuable resource for investigations of the patterning of neurogenesis and transition of progenitors to neuronal differentiation.
Development presents... live stream of our Journal Meeting

Watch a session from Development’s Journal Meeting, Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology which was live on the Node Monday 18 September.
Navigating a research career with a disability

Our two recent Perspectives articles explore the lived experiences of disabled scientists in our community. Kelsey L. Anbuhl and colleagues describe the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability. Whereas Jack Darius Morgan reviews the literature exploring disabled scientists’ experiences in academia.
Focus on regeneration

Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. Here, Development has collated a series of articles showcasing some of the most recent advances in regenerative biology.
Keeping up with the Node: Lab meetings

Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. August featured the Nichols lab at the University of Edinburgh, read their 'Lab meeting' article here.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.