Issues
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Cover image
Cover Image
Cover: Dorsal view of the abdominal epidermis of a Drosophila pupa stained for E-cadherin to visualize cell junctions (white). The small histoblasts (cyan and black) proliferate and replace the large larval epidermal cells. Larval epidermal cells of one segment are coloured according to their position at the time of their extrusion: at the border of the histoblast nest (yellow), at the dorsal midline (green) or in between (magenta). See Research article by Michel and Dahmann (dev179606).
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RESEARCH HIGHLIGHTS
EDITORIAL
Developing new associations
Summary: In this Editorial, we announce the recruitment of several Associate Editors to cover new and expanding areas of developmental biology. We also discuss various policies and initiatives to improve transparency and efficiency in our editorial processes.
INTERVIEW
REVIEWS
Skeletal stem cells: insights into maintaining and regenerating the skeleton
Summary: This Review summarizes recent progress in the isolation and characterization of stem cell populations that build, maintain and repair the vertebrate skeleton, outlining the challenges in this growing field and highlighting promising new avenues of research.
Integration of luminal pressure and signalling in tissue self-organization
Summary: Lumen formation provides both mechanical and biochemical cues to influence cellular behaviours and ensure robust morphogenesis and patterning during development.
STEM CELLS AND REGENERATION
Histone variant dictates fate biasing of neural crest cells to melanocyte lineage
Summary: This study reports a mechanism underpinning the crucial role of histone variant H2A.Z.2 in fate allocation and subsequent commitment of melanocyte identity, from a multipotent state.
Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium
Summary: Estrogen receptor (ER) α palmitoylation is required for mammary epithelial cell stem cell function, intercellular and intercompartmental communication with altered expression of paracrine factors and impaired ECM remodeling/protease function.
RESEARCH REPORT
Wingless counteracts epithelial folding by increasing mechanical tension at basal cell edges in Drosophila
Highlighted Article: Wingless signaling activity controls cell shape and mechanical tension to guide the morphogenesis of Drosophila wing discs.
RESEARCH ARTICLES
Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated
Highlighted Article: Analysis of the requirement for Grainy head in determining chromatin accessibility at multiple stages of Drosophila development demonstrates that its pioneering activity is temporally regulated and not essential in the early embryo.
Oxidative stress regulates progenitor behavior and cortical neurogenesis
Summary: Reactive oxygen species and oxidative stress regulated by the transcriptional regulator PRDM16 actively influence radial glial progenitor mitotic behavior and precise neuronal output in the developing mouse cortex.
Multiple lineages enable robust development of the neuropil-glia architecture in adult Drosophila
Summary: During metamorphosis, larval ensheathing glia (EG) dedifferentiate, proliferate and redifferentiate into two adult glial subtypes. With developmental plasticity, two lineages (larval EG and gcm-positive lineages) ensure the robust development of adult neuropil-glia architecture.
Tissue mechanical properties modulate cell extrusion in the Drosophila abdominal epidermis
Highlighted Article: A developmental switch in the cell extrusion mechanism correlates with changes in cell mechanical properties during tissue replacement in the Drosophila abdominal epidermis.
Control of tissue morphogenesis by the HOX gene Ultrabithorax
Highlighted Article: The HOX gene Ubx governs the wing-to-haltere transformation in dipteran insects by regulating expression of proteases that control ECM remodelling to disrupt wing elongation and flattening.
The Rheb-TORC1 signaling axis functions as a developmental checkpoint
Summary: RHEB-1 and DAF-15/Raptor, components of the nematode TORC1 complex, are necessary for animals to progress through each stage of post-embryonic development. Restoration of DAF-15 after depletion leads to resumed development.
Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation
Summary: The transcription factor Pbx4 restricts outflow tract size in the zebrafish heart by reinforcing distinct cardiac progenitor differentiation states.
CORRECTION
PREPRINT HIGHLIGHTS
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