Issues
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Cover image
Cover Image
Cover: Scanning electron micrograph of the junction of the internal and external jugular vein with the superior vena cava in an E16.5 mouse embryo. Venous valves that guard the jugular veins are highlighted in green. Lymphovenous valves that prevent back flow of venous blood into lymphatic sacs are highlighted in magenta. Development of both types of valve is blocked in embryos that lack the RASA1 Ras-GTPase-activating protein. See Research article by Chen et al. (dev192351)
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RESEARCH HIGHLIGHTS
INTERVIEW
An interview with Claude Desplan
Summary: Claude Desplan, recently awarded the Society for Developmental Biology's Edwin G. Conklin Medal, discusses his career progression, how he became interested in neural development, and his approach to mentoring young scientists.
SPOTLIGHT
Towards understanding the origin of animal development
Summary: This Spotlight discusses developmental similarities between protist lineages and animals, highlighting how studying these protists could provide crucial insights into the early evolution of animal development.
HYPOTHESIS
Neuronal differentiation strategies: insights from single-cell sequencing and machine learning
Summary: This Hypothesis article outlines a new approach to designing in vitro neuronal differentiation protocols, capitalizing on recent developments in single-cell mRNA sequencing and machine learning algorithms to define neuronal developmental trajectories.
REVIEWS
Nuclear pore complexes in development and tissue homeostasis
Summary: Nuclear pore complexes and their components have been found to play multiple functions in embryogenesis, cell differentiation and tissue-specific processes. Many of them are performed in a transport-independent manner. This Review highlights the roles of nucleoporins in during development and tissue homeostasis.
Retinal ganglion cell interactions shape the developing mammalian visual system
Summary: This Review summarizes the extensive roles of retinal ganglion cell interactions in shaping cell migration, vascular development, circuit formation and behavior, before the onset of vision in mammals.
HUMAN DEVELOPMENT
Epithelial dynamics shed light on the mechanisms underlying ear canal defects
Highlighted Article: We reveal new mechanisms that control development of the ear canal and highlight for the first time the complex system of canal closure and reopening.
E2A regulates neural ectoderm fate specification in human embryonic stem cells
Summary: E2A brings context specificity to the expression of neural genes and the NODAL signaling pathway to control lineage-specific gene expression and cell fate determination during early human development.
STEM CELLS AND REGENERATION
H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells
Summary: SUV420H2 regulation of H4K20me3-marked heterochromatin controls the chromatin structure of embryonic stem cells, where loss of SUV420H2 results in dysregulated gene expression and differentiation, altered 3D chromatin interactions, compartment switching and perturbed chromatin insulation.
RESEARCH REPORTS
CNS macrophages differentially rely on an intronic Csf1r enhancer for their development
Summary: Deletion of the fms-intronic regulatory element of Csf1r in mouse disrupts the engraftment and maintenance of central nervous system macrophages in a compartment-specific manner.
Increased lateral tension is sufficient for epithelial folding in Drosophila
Highlighted Article: Optogenetic activation of RhoGEF2 at lateral cell sides drives epithelial folding in Drosophila wing discs.
RESEARCH ARTICLES
The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development
Summary: There are dual, tissue-specific roles for the hedgehog co-receptor BOC in both the promotion and antagonism of hedgehog signaling during craniofacial development.
Kctd15 regulates nephron segment development by repressing Tfap2a activity
Summary: kctd15 paralogs regulate nephron segment commitment and differentiation through repressor-mediated genetic feedback with tfap2a. This fundamentally deepens our knowledge about the genetic control of kidney development.
Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication
Summary: Localization of BAF at the nuclear envelope of myonuclei depends on a functional LINC complex and on nucleus-sarcomere connections, and is shown to restrict E2F1 levels in the nucleoplasm.
The RNA-dependent DNA methylation pathway is required to restrict SPOROCYTELESS/NOZZLE expression to specify a single female germ cell precursor in Arabidopsis
Highlighted Article: The control of SPL/NZZ expression by the RdDM pathway and STK is essential for the formation of a single female germline precursor in Arabidopsis.
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
Summary: YAP and TAZ mediate the positive feedback loop between PROX1 and VEGF-C signaling in the developing lymphatic and lymphovenous valves.
Molecular mechanisms underlying simplification of venation patterns in holometabolous insects
Summary: We describe the expression pattern and function of candidate venation patterning genes in butterflies and propose how the simplified venation of flies might have evolved from a common ancestor of both flies and butterflies.
Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity
Highlighted Article: By regulating actin pool distribution and incorporation into junctional actin networks, thymosin β4 regulates cell–cell adhesion, planar cell polarity and epidermal morphogenesis.
RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice
Summary: Development of lymphovenous and venous valves is dependent upon the RASA1 Ras GTPase-activating protein that facilitates endothelial cell export of the vascular basement protein collagen IV.
CORRECTION
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.